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NativeExtract™ Human ADRA2A Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX327)

Datasheet
This product is recombinant Human ADRA2A protein in native nanodisc form. The synthetic compound we developed can solubilize the ADRA2A protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • ADRA2A
  • Protein Length
  • Full length
  • Molecular Weight
  • 50.6kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • ADRA2A
  • Full Name
  • Adrenoceptor alpha 2A
  • Introduction
  • Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. The alpha-2-adrenergic receptors are a type of adrenergic receptors (for adrenaline or epinephrine), which inhibit adenylate cyclase. These receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. They are involved in regulating the release of neurotransmitter molecules from sympathetic nerves and from adrenergic neurons in the central nervous system. The sympathetic nervous system regulates cardiovascular function by activating adrenergic receptors in the heart, blood vessels and kidney. Studies in mouse revealed that both the alpha2A and alpha2C receptor subtypes were required for presynaptic transmitter release from the sympathetic nervous system in the heart and from central noradrenergic neurons. The alpha-2-adrenergic receptors are also involved in catecholamine signaling by extracellular regulated protein kinase 1 and 2 (ERK1/2) pathways. A clear association between the alpha-2-adrenergic receptor and disease has not been yet established.
  • Alternative Names
  • ADRA2; ADRAR; ZNF32; ADRA2R; ALPHA2AAR; adrenergic, alpha-2A-, receptor; alpha-2 adrenergic receptor subtype C10; alpha-2-adrenergic receptor, platelet type; alpha-2A adrenoceptor; alpha-2A adrenoreceptor; alpha-2AAR subtype C10; ADRA2A; Adrenoceptor alpha 2A

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