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NativeExtract™ Human CCR7 Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX460)

Datasheet
This product is recombinant Human CCR7 protein in native nanodisc form. The synthetic compound we developed can solubilize the CCR7 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CCR7
  • Protein Length
  • Full length
  • Molecular Weight
  • 42.9 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • CCR7
  • Full Name
  • C-C motif chemokine receptor 7
  • Introduction
  • The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants.
  • Alternative Names
  • BLR2; EBI1; CCR-7; CD197; CDw197; CMKBR7; CC-CKR-7; C-C chemokine receptor type 7; Bukitt's lymphoma receptor 2; CC chemokine receptor 7; EBV-induced G protein-coupled receptor 1; Epstein-Barr virus induced gene 1; Epstein-Barr virus-induced G-protein coupled receptor 1; MIP-3 beta receptor; chemokine (C-C motif) receptor 7; lymphocyte-specific G protein-coupled peptide receptor; CCR7; C-C motif chemokine receptor 7

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