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NativeExtract™ Human CXCR4 Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX447)

Datasheet
This product is recombinant Human CXCR4 protein in native nanodisc form. The synthetic compound we developed can solubilize the CXCR4 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CXCR4
  • Protein Length
  • Full length
  • Molecular Weight
  • 39.7 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • CXCR4
  • Full Name
  • C-X-C motif chemokine receptor 4
  • Introduction
  • This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
  • Alternative Names
  • FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; WHIMS; HSY3RR; NPYY3R; D2S201E; C-X-C chemokine receptor type 4; CD184 antigen; LPS-associated protein 3
    SDF-1 receptor; chemokine (C-X-C motif) receptor 4; fusin; leukocyte-derived seven transmembrane domain receptor; lipopolysaccharide-associated protein 3; neuropeptide Y receptor Y3
    neuropeptide Y3 receptor; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; stromal cell-derived factor 1 receptor; CXCR4; C-X-C motif chemokine receptor 4

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