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NativeExtract™ Human CXCR6 Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX372)

Datasheet
This product is recombinant Human CXCR6 protein in native nanodisc form. The synthetic compound we developed can solubilize the CXCR6 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CXCR6
  • Protein Length
  • Full length
  • Molecular Weight
  • 39.3 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • CXCR6
  • Full Name
  • C-X-C motif chemokine receptor 6
  • Introduction
  • The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the CXC chemokine receptor family. This family also includes CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR7. This gene, which maps to the chemokine receptor gene cluster, is expressed in several T lymphocyte subsets and bone marrow stromal cells. The encoded protein and its exclusive ligand, chemokine ligand 16 (CCL16), are part of a signalling pathway that regulates T lymphocyte migration to various peripheral tissues (the liver, spleen red pulp, intestine, lungs, and skin) and promotes cell-cell interaction with dendritic cells and fibroblastic reticular cells. CXCR6/CCL16 also controls the localization of resident memory T lymphocytes to different compartments of the lung and maintains airway resident memory T lymphocytes, which are an important first line of defense against respiratory pathogens. The encoded protein serves as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4.
  • Alternative Names
  • BONZO; CD186; CDw186; STRL33; TYMSTR; C-X-C chemokine receptor type 6; G protein-coupled receptor; G-protein coupled receptor STRL33; G-protein coupled receptor bonzo; chemokine (C-X-C motif) receptor 6; CXCR6; C-X-C motif chemokine receptor 6

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