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NativeExtract™ Human EDNRB Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX278)

Datasheet
This product is recombinant Human EDNRB protein in native nanodisc form. The synthetic compound we developed can solubilize the EDNRB protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • EDNRB
  • Protein Length
  • Full length
  • Molecular Weight
  • 49.6kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • EDNRB
  • Full Name
  • Endothelin receptor type B
  • Introduction
  • The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
  • Alternative Names
  • ETB; ET-B; ETB1; ETBR; ETRB; HSCR; WS4A; ABCDS; ET-BR; HSCR2; Hirschsprung disease 2; endothelin receptor non-selective type; endothelin receptor subtype B1; EDNRB; Endothelin receptor type B

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