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NativeExtract™ Human FZD6 Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX267)

Datasheet
This product is recombinant Human FZD6 protein in native nanodisc form. The synthetic compound we developed can solubilize the FZD6 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • FZD6
  • Protein Length
  • Full length
  • Molecular Weight
  • 79.3kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • FZD6
  • Full Name
  • Frizzled class receptor 6
  • Introduction
  • This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.
  • Alternative Names
  • FZ6; FZ-6; HFZ6; NDNC1; NDNC10; frizzled-6; frizzled 6, seven transmembrane spanning receptor; frizzled family receptor 6; frizzled homolog 6; seven transmembrane helix receptor; FZD6; Frizzled class receptor 6

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