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NativeExtract™ Human FZD7 Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX386)

Datasheet
This product is recombinant Human FZD7 protein in native nanodisc form. The synthetic compound we developed can solubilize the FZD7 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • FZD7
  • Protein Length
  • Full length
  • Molecular Weight
  • 63.6 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • FZD7
  • Full Name
  • Frizzled class receptor 7
  • Introduction
  • Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
  • Alternative Names
  • FzE3; frizzled-7; Frizzled, drosophila, homolog of, 7; frizzled 7, seven transmembrane spanning receptor; frizzled family receptor 7; frizzled homolog 7; fz-7; hFz7; FZD7; Frizzled class receptor 7

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