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NativeExtract™ Human FZD8 Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX266)

Datasheet
This product is recombinant Human FZD8 protein in native nanodisc form. The synthetic compound we developed can solubilize the FZD8 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • FZD8
  • Protein Length
  • Full length
  • Molecular Weight
  • 73.3kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • FZD8
  • Full Name
  • Frizzled class receptor 8
  • Introduction
  • This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
  • Alternative Names
  • frizzled 8, seven transmembrane spanning receptor; frizzled family receptor 8; frizzled homolog 8FZ-8; hFZ8; frizzled-8; FZD8; Frizzled class receptor 8

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