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NativeExtract™ Human GIPR Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX366)

Datasheet
This product is recombinant Human GIPR protein in native nanodisc form. The synthetic compound we developed can solubilize the GIPR protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GIPR
  • Protein Length
  • Full length
  • Molecular Weight
  • 53.2 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • GIPR
  • Full Name
  • Gastric inhibitory polypeptide receptor
  • Introduction
  • This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes.
  • Alternative Names
  • PGQTL2; gastric inhibitory polypeptide receptor; GIP-R; glucose-dependent insulinotropic polypeptide receptor; GIPR; Gastric inhibitory polypeptide receptor

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