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NativeExtract™ Human GPBAR1 Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX226)

Datasheet
This product is recombinant Human GPBAR1 protein in native nanodisc form. The synthetic compound we developed can solubilize the GPBAR1 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GPBAR1
  • Protein Length
  • Full length
  • Molecular Weight
  • 35.2kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • GPBAR1
  • Full Name
  • G protein-coupled bile acid receptor 1
  • Introduction
  • This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein.
  • Alternative Names
  • BG37; TGR5; M-BAR; GPCR19; GPR131; G-protein coupled bile acid receptor 1; G-protein coupled bile acid receptor BG37; G-protein coupled receptor GPCR19; membrane bile acid receptor; membrane-type receptor for bile acids; GPBAR1; G protein-coupled bile acid receptor 1

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