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NativeExtract™ Human HTR2A Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX347)

Datasheet
This product is recombinant Human HTR2A protein in native nanodisc form. The synthetic compound we developed can solubilize the HTR2A protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • HTR2A
  • Protein Length
  • Full length
  • Molecular Weight
  • 52.6kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • HTR2A
  • Full Name
  • 5-hydroxytryptamine receptor 2A
  • Introduction
  • This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Alternative Names
  • HTR2; 5-HT2A; 5-HT2 receptor; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; serotonin 5-HT-2A receptor; HTR2A; 5-hydroxytryptamine receptor 2A

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