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NativeExtract™ Human OPRM1 Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX129)

Datasheet
This product is recombinant Human OPRM1 protein in native nanodisc form. The synthetic compound we developed can solubilize the OPRM1 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • OPRM1
  • Protein Length
  • Full length
  • Molecular Weight
  • 44.8kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • OPRM1
  • Full Name
  • Opioid receptor mu 1
  • Introduction
  • This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains.
  • Alternative Names
  • MOP; MOR; LMOR; MOR1; OPRM; M-OR-1; mu-type opioid receptor; mu opiate receptor; mu opioid receptor hMOR-1a; OPRM1; Opioid receptor mu 1

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