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NativeExtract™ Human TLR5 Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX457)

Datasheet
This product is recombinant Human TLR5 protein in native nanodisc form. The synthetic compound we developed can solubilize the TLR5 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • TLR5
  • Protein Length
  • Full length
  • Molecular Weight
  • 97.8 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • TLR5
  • Full Name
  • Toll like receptor 5
  • Introduction
  • This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.
  • Alternative Names
  • TLR5; SLE1; TIL3; SLEB1; MELIOS; toll-like receptor 5; systemic lupus erythematosus susceptibility 1; toll/interleukin-1 receptor-like protein 3; Toll like receptor 5

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