- This product is an antibody that was generated by immunizing mouse against Amino acids 57-84 (CFDDTVRGVPWCFYPNTIDVPPEEECEF) from the human protein. It is used only in in vitro assays.
Detailed Product Description
- Introduction: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.
- Conjugate: None
- Antibody Isotype: IgG1κ
- Applications: Flow Cytometry; IF; IHC
Technical Specifications
- Host Species: Mouse
- Species Reactivity: Cynomolgus; Human
- Immunogen: Amino acids 57-84 (CFDDTVRGVPWCFYPNTIDVPPEEECEF) from the human protein
Product Property
- Purification: Protein G affinity chromatography
- Format: Liquid
- Concentration: 0.2 mg/mL
- Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
- Storage: Store at 4⁰C. Avoid freeze-thaw cycles.
Target Information
- Target: pS2
- Clone: NR3G
- Clonality: Monoclonal
- Alternative Names: AD3LP; AD5; Alzheimer disease 4; E5-1; Presenilin-2; Presenilin-2 CTF subunit; Presenilin-2 NTF subunit; PS-2; PSEN 2; STM-2
- Entrez Gene ID: 7031
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