pS2 Monoclonal Antibody (NR3G) (NHP-AB164)


  • This product is an antibody that was generated by immunizing mouse against Amino acids 57-84 (CFDDTVRGVPWCFYPNTIDVPPEEECEF) from the human protein. It is used only in in vitro assays.

Detailed Product Description

  • Introduction: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.
  • Conjugate: None
  • Antibody Isotype: IgG1κ
  • Applications: Flow Cytometry; IF; IHC

Technical Specifications

  • Host Species: Mouse
  • Species Reactivity: Cynomolgus; Human
  • Immunogen: Amino acids 57-84 (CFDDTVRGVPWCFYPNTIDVPPEEECEF) from the human protein

Product Property

  • Purification: Protein G affinity chromatography
  • Format: Liquid
  • Concentration: 0.2 mg/mL
  • Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
  • Storage: Store at 4⁰C. Avoid freeze-thaw cycles.

Target Information

  • Target: pS2
  • Clone: NR3G
  • Clonality: Monoclonal
  • Alternative Names: AD3LP; AD5; Alzheimer disease 4; E5-1; Presenilin-2; Presenilin-2 CTF subunit; Presenilin-2 NTF subunit; PS-2; PSEN 2; STM-2
  • Entrez Gene ID: 7031
Downloadable Resources Customer Reviews
  • pS2 Monoclonal Antibody (NR3G) (NHP-AB164) Data Sheet: Detailed information.

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NHP Biologicals from Creative Biolabs are for research, diagnostic, or manufacturing purposes only. They may not be intended for or are not approved for any other use.

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