Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe SLC36 family of proton-coupled amino acid transporters consists of four members, SLC36A1 to SLC36A4. These proteins are involved in the transmembrane movement of amino acids and derivatives.
The ionic coupling and substrate selectivity of the SLC36A1 and SLC36A2 transporters are unusual. Unlike most of mammalian amino acid transporters that function as exchangers or Na+/amino acid symporters, they act as H+/amino acid symporters. SLC36A1, which is expressed at the luminal surface of the human small intestine, is the most thoroughly characterized of the SLC36 family. SLC36A1 can transport a broad range of amino acids and many orally-active amino acid-based drugs and derivatives (including a variety of GABA- and proline-related compounds which can be used for experimental and/or clinical treatment of infections, diabetes, epilepsy, schizophrenia, homocystinuria, cancer cell growth (in vitro) and in photodynamic therapy, fluorescent diagnosis and fluorescent-guided resection of cancer. SLC36A2 is expressed in the apical membrane of the renal proximal tubule. It is involved in the reabsorption of amino acids and derivatives from the renal filtrate. Defects in SLC36A2 result in iminoglycinuria and hyperglycinuria. The function of the two transporters appears to influence the pharmacokinetic profile of amino acid-based drugs by mediating absorption in the small intestine and reabsorption in the kidney.
Fig.1 The H+-coupled amino acid transporter PAT1 (SLC36A1) can transport a number of compounds with potential therapeutic value (shown in blue). (Thwaites, 2011)
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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