One-Stop CAR-T Therapy Development www.creative-biolabs.com/car-t/

Creative Biolabs is a world-renowned immunotherapy service provider. We have one of the world’s largest collection of CAR products of different generations targeting various biomarkers, and we continue to innovate the next generation CAR technologies to achieve even greater results. Based on advanced technologies and years of research, Creative Biolabs offers high-quality custom services covering the entire CAR-T therapy development process to best suit your technical, program and budget requirements and greatly assist your research, preclinical investigation and clinical stage development.

Biomarker Identification & Selection •  De novo discovery of potential cancer biomarkers by multiple gene and protein analysis technologies •  Selection of the most suitable CAR-T therapy targets with greater potency and lower toxicity CAR Design & Construction •  Design and construction of CARs of different generations •  SmartTM CAR platform for the next generation CAR discovery •  Customized lentiviral or retroviral CAR construction CAR-T In Vitro Assay •  CAR expression validation •  CAR-T cell proliferation •  Multiplex cytokine screening •  Cytotoxicity test against target cells IND Development for CAR-T Cell Therapy •  Clinical trial protocols •  USFDA IND/ANDA documents submission •  Custom IND studies CAR-T Clinical Trial •  Study design and filing •  Project management and execution •  Data management and biostatistics •  QA&QC High Affinity ScFv Generation •  A collection of over 6000 antibody products •  In-house antibody sequence database •  Antibody discovery by hybridomas, mouse, rabbit and human library •  scFv sequencing and NGS of hybridomas or phage libary •  scFv affinity measurement and optimization Virus Packaging & CAR Gene Delivery •  High titer transduction-ready pseudoviral particles produced by our cell manufacture platform •  GMP virus manufacturing for clinical trials and applications •  Strict quality control •  Various transfection technology available •  Transfection method tailored for different cell types CAR-T Preclinical In Vivo Assay •  Construction of xenograft animal model •  Efficacy test of CAR-T cells •  Viability and bio-distribution study of CAR-T cells •  Toxicity evaluation of CAR-T cells •  GLP-compliant assays GMP Production for CAR-T Products •  GMP-level plasmid manufacture •  GMP-level virus packaging •  GMP-level CAR-T cell production

USA SUITE 203, 17 Ramsey Road, Shirley, NY 11967. USA Tel: 1-631-381-2994 Fax: 1-631-207-8356 Email: info@creative-biolabs.com Copyright © 2020 Creative Biolabs. All Rights Reserved.