SLC16A13 Membrane Protein Introduction

Introduction of SLC16A13

SLC16A13 is also known as Monocarboxylate transporter 13 (MCT 13) and Solute carrier family 16 member 13. It is a member of the solute carrier family 16 (SLC16) family or monocarboxylate transporter (MCT) family, which contains 14 solute carriers defined by two highly conserved sequences. Three-dimensional homology modeling of SLC16A13 suggests that SLC16A13 possess 12 transmembrane alpha helices and 2 topological domains.

Basic Information of SLC16A13
Protein Name	Monocarboxylate transporter 13
Gene Name	SLC16A13
Aliases	MCT13, Solute carrier family 16 member 13
Organism	Homo sapiens (Human)
UniProt ID	Q7RTY0
Transmembrane Times	12
Length (aa)	426
Sequence	MARRTEPPDGGWGWVVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPVVMTGGILAALGMLLASFATSLTHLYLSIGLLSGSGWALTFAPTLACLSCYFSRRRSLATGLALTGVGLSSFTFAPFFQWLLSHYAWRGSLLLVSALSLHLVACGALLRPPSLAEDPAVGGPRAQLTSLLHHGPFLRYTVALTLINTGYFIPYLHLVAHLQDLDWDPLPAAFLLSVVAISDLVGRVVSGWLGDAVPGPVTRLLMLWTTLTGVSLALFPVAQAPTALVALAVAYGFTSGALAPLAFSVLPELIGTRRIYCGLGLLQMIESIGGLLGPPLSGYLRDVTGNYTASFVVAGAFLLSGSGILLTLPHFFCFSTTTSGPQDLVTEALDTKVPLPKEGLEED

Function of SLC16A13 Membrane Protein

SLC16A13 is expressed in large parts of the cortex hippocampus, hypothalamus, and cerebellum with minor differences in expression in some structures. SLC16A13 protein is present in these same areas and is expressed in almost all neurons and some supporting cells. Seven additional members of the MCT family (MCT5, MCT7, MCT9, AND MCT11–14) have been identified through searching of the human genomic and EST databases. Riboflavin has been suggested as a substrate for SLC16A13 based on its sequence homology to Mch5p, which is responsible for plasma membrane uptake of riboflavin in Saccharomyces cerevisiae. Some studies have demonstrated that MCT13 (SLC16A13) was induced by PPAR-α agonists in mouse liver and small intestine, suggesting that this transporter may be involved in nutrient uptake. Further studies are required to elucidate the exact mechanism of induction via this pathway and the role of PPAR-α in the overall regulation of MCT13.

SLC16A13 Membrane Protein Introduction Fig.1 Proposed structure of SLC16A13 membrane protein. (Lomakin,2017)

Application of SLC16A13 Membrane Protein in Literature

Hara K., et al. Genome-wide association study identifies three novel loci for type 2 diabetes. Hum. Mol. Genet. 2014, 23(1):239-246. PubMed ID: 23945395

Authors in this article apply the genome-wide association study of 6 209 637 single-nucleotide polymorphisms to demonstrate that the mutations of SLC16A13 are involved in regulating the type 2 diabetes.
Kirat D., et al. Presence of ten isoforms of monocarboxylate transporter (MCT) family in the bovine adrenal gland. Mol. Cell. Endocrinol. 2009, 298(1):89-100. PubMed ID: 18996437

This study provides novel information regarding the existence and precise cellular localization of various MCT isoforms in the mammalian adrenal gland.
Kirat D., et al. Regional and cellular distribution of monocarboxylate transporters 13 and 14 in the cattle gastrointestinal tract. Mol. Cell. Endocrinol. 2015, 61(3):39-45. PubMed ID: 26081812

This article reveals the distinct regional distribution in gene expression profiles of both MCT13 and MCT14. The data of this article might be beneficial in future research to understand their physiological role in the ruminant gastrointestinal tract.
Morris M.E., et al. Overview of the Proton-coupled MCT (SLC16A) Family of Transporters: Characterization, Function and Role in the Transport of the Drug of Abuse γ-Hydroxybutyric Acid. The AAPS Journal. 2008, 10(2):311. PubMed ID: 18523892

This article reviews the function of MCTs and indicates that MCTs represent an important family of transport proteins involved in the transport of endogenous and exogenous compounds.
Halestrap AP., et al. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem. J. 1999, 343(Pt 2):281-299. PubMed ID: 10510291

This article reports that MCTs play important roles in cellular metabolism and metabolic communication between tissues. Meanwhile, there is still much work to be done to characterize the properties of the different MCTs and their regulation, which may have wide-ranging implications for health and disease.

SLC16A13 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLC16A13 antibody development services.

As a forward-looking research institute as well as a leading custom service provider in the field of membrane protein, Creative Biolabs has built up a custom-service-centered business model for our worldwide customers to accomplish numerous challenging projects including generation of many functional membrane proteins successfully. Please feel free to contact us for more information.

Reference

Lomakin IB., et al. (2017) Crystal structure of the human ribosome in complex with DENR-MCT-1. Cell reports. 20(3):521-528

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

	USA: Europe: Germany:
	Call us at: USA: UK: Germany:
	Fax:
	Email: