SLC16A9 Membrane Protein Introduction

Introduction of SLC16A9

Solute carrier family 16 member 9 (SLC16A9), also known as monocarboxylate transporter 9 (MCT9), is encoded by SLC16A9 gene. SLC16A9 belongs to the monocarboxylate transporter family and is ubiquitously expressed in the body, especially in the kidney with a high level. The function of SLC16A9 is not clearly known, but SLC16A9 has a close relationship with serum uric acid. It is a member of the solute-carrier transporter family that is expressed in several urate-excreting organs, including intestine and kidney.

Basic Information of SLC16A9
Protein Name	Monocarboxylate transporter 9
Gene Name	SLC16A9
Aliases	Solute carrier family 16 member 9
Organism	Homo sapiens (Human)
UniProt ID	Q7RTY1
Transmembrane Times	12
Length (aa)	509
Sequence	MELKKSPDGGWGWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAGGLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCLLIVGALALNILACGSLMRPLQSSDCPLPKKIAPEDLPDKYSIYNEKGKNLEENINILDKSYSSEEKCRITLANGDWKQDSLLHKNPTVTHTKEPETYKKKVAEQTYFCKQLAKRKWQLYKNYCGETVALFKNKVFSALFIAILLFDIGGFPPSLLMEDVARSSNVKEEEFIMPLISIIGIMTAVGKLLLGILADFKWINTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFLTGNWSIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLAALPSWDTCNKQLPKPAPTTFLYKVASN

Function of SLC16A9 Membrane Protein

The single nucleotide polymorphism (SNP) of SLC16A9 gene is closely related to human blood uric acid levels, and when SLC16A9 amino acid K258T is mutated, the incidence of renal overload gout is significantly higher, suggesting a possible correlation of SLC16A9 in the extra-renal uric acid excretion pathway. The uric acid excretion process of SLC16A9 in intestinal epithelial cells has also been confirmed to be associated with K258T mutant. In addition, a missense variant of SLC16A9, rs2242206, can significantly increase the risk of renal overload gout, indicating that rs2242206 relates to decreased intestinal urate excretion rather than decreased renal urate excretion.

SLC16A9 Membrane Protein Introduction Fig.1 TRPM7 and the associated molecular pathways regulating tumor growth and spreading. (Federica, 2012)

Application of SLC16A9 Membrane Protein in Literature

Jorge A.S. Renal Handling of Uric Acid. Contrib Nephrol. 2018, 192: 1-7. PubMed ID: 29393102

This article reveals that the amount of uric acid excreted affects the function of transporters.
Xu X., et al. Uric acid transporters hiding in the intestine. Pharm Biol. 2016, 54(12): 3151-3155. PubMed ID: 27563755

This article demonstrates that the solute carrier (SLC) transporters include GLUT9, MCT9, NPT4, NPT homolog (NPT5) and OAT10.
Nakayama A., et al. Common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility. Hum Cell. 2013, 26(4): 133-136. PubMed ID: 23990105

This article demonstrates that a missense variant of MCT9 (K258T) - rs2242206, can significantly increase the risk of renal overload gout. And the common missense variant rs2242206 is revealed to have an association with renal overload gout, indicating that rs2242206 relates to decreased intestinal urate excretion rather than decreased renal urate excretion.
Ichida K., et al. What lies behind serum urate concentration? Insights from genetic and genomic studies. Nature communications. 2009, 1(12): 118. PubMed ID: 20090896

This article demonstrates that MCT9 is expressed in the parathyroid, kidney, trachea, spleen and adrenal gland.
Hoshino D., et al. Cellular expression of the monocarboxylate transporter (MCT) family in the placenta of mice. Placenta. 2009, 31(2): 126-133. PubMed ID: 20022372

The authors use an in situ hybridization survey of all MCT subtypes and detect intense mRNA expressions of MCT1, MCT4, and MCT9 as well as GLUT1 in the placenta from gestational day 11.5.

SLC16A9 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLC16A9 antibody development services.

Creative Biolabs' skillful scientists are glad to leverage our expertise and advanced technologies to help you with the member protein research. If you are interested, please feel free to contact us for more details.

Reference

Federica I Wolf. (2000). Magnesium and its transporters in cancer: a novel paradigm in tumour development. Clinical Science. 123(7): 417-427.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

	USA: Europe: Germany:
	Call us at: USA: UK: Germany:
	Fax:
	Email: