SLC22A12 Membrane Protein Introduction

Introduction of SLC22A12

The solute family 22, member 12 (SLC22A12), is a protein that is encoded by the SLC22A12 gene in humans. It is also known as Urate anion exchanger 1(URAT1). SLC22A12 is an organic anion/cation transporter. The protein encoded by this gene is a urine transporter and urate-anion exchanger that regulates uric acid levels in the blood. This protein is a complete membrane protein found primarily in the kidneys. Two transcripts encoding different isoforms were found for this gene.

Basic Information of SLC22A12
Protein Name	Solute carrier family 22 member 12
Gene Name	SLC22A12
Aliases	Organic anion transporter 4-like protein, Renal-specific transporter (RST), Urate anion exchanger 1
Organism	Homo sapiens (Human)
UniProt ID	Q96S37
Transmembrane Times	12
Length (aa)	553
Sequence	MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF

Function of SLC22A12 Protein

SLC22A12 is considered to be responsible for the renal re-absorption of a medically important compound, the transporter of uric acid. Many single nucleotide polymorphisms in this gene are significantly associated with uric acid reabsorption (increased or decreased) in the kidney. These altered rates of resorption can lead to hyperuricemia and hypoxemia. Family renal hypotension is caused by defects in the renal tubular tract. This disorder is mainly caused by a mutation in the gene SLC22A12, which is the encoding of human urate transmitter 1 (URAT1). SLC22A12 affects uric acid reabsorption in the kidneys and regulates the urate content in the blood by promoting saturable urate uptake of organic anion exchange urate.

Fig.1 The structure of SLC22A12 Protein.

Application of SLC22A12 Protein in Literature

Hurba O., et al. Complex Analysis of Urate Transporters SLC2A9, SLC22A12 and Functional Characterization of Non-Synonymous Allelic Variants of GLUT9 in the Czech Population: No Evidence of Effect on Hyperuricemia and Gout. PLoS ONE. 2014, 9 (9): e107902. PubMed ID: 25268603.

These results confirm that SLC22A12 and SLC2A9 variants have no effect on serum uric acid concentration.
Sakiyama M., et al. The effects of URAT1/SLC22A12 nonfunctional variants, R90H and W258X, on serum uric acid levels and gout/hyperuricemia progression. Scientific Reports. 2016, (6):20148. PubMed ID: 26821810.

The authors demonstrate the gender-dependent size of these URAT1 variants on SUA and imply that URAT1 non-functional variation is a protective genetic factor leading to gout/hyperuricemia.
Vidanapathirana D.M., et al. A Heterozygous Variant in the SLC22A12 Gene in a Sri Lanka Family Associated with Mild Renal Hypouricemia. BMC Pediatrics. 2018, (18): 210. PubMed ID: 29958533.

These findings confirm the geographical and ethnic distribution of the SLC22A12 variant that is prevalent in the Romans, which is a consideration for Asian patients.
Zhou Z.W., et al. Polymorphisms in GCKR, SLC17A1 and SLC22A12 Were Associated with Phenotype Gout in Han Chinese Males: A Case–control Study. BMC Medical Genetics. 2015, (16): 66. PMC. Web. 22 July 2018.PubMed ID: 26290326.

This article reveals that there are three SUA-related SNPs in the Caucasus, rs780094 of GCKR, rs1183201 of SLC17A1, and rs505802 of SLC22A12, which have been confirmed to be associated with gouty arthritis and uric acid concentration in Chinese Han males.
Kim H.O., et al. A Case Report of Familial Renal Hypouricemia Confirmed by Genotyping of SLC22A12, and a Literature Review. Electrolytes & Blood Pressure: E & BP. 2015, 13 (2): 52–57. PubMed ID: 26848304.

This article reports a case of familial renal hypotension, confirmed by SLC22A12 genotype identification, and review related literature.

SLC22A12 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLC22A12 antibody development services.

Creative Biolabs' skillful scientists are glad to leverage our expertise and advanced technologies to help you with the member protein research. If you are interested, please feel free to contact us for more details.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

	USA: Europe: Germany:
	Call us at: USA: UK: Germany:
	Fax:
	Email: