SLC6A2 Membrane Protein Introduction

Introduction of SLC6A2

SLC6A2 is encoded by SLC6A2 gene. It belongs to the solute carrier family 6 which has been extensively studied during the past few decades because it offers numerous possibilities for therapeutic applications. It is a norepinephrine transporter which can remove norepinephrine into presynaptic nerve terminals, and is responsible for regulating norepinephrine homeostasis. Meanwhile, many studies conducted on SLC6A2 show that it is related to various diseases, such as orthostatic intolerance and syncope.

Function of SLC6A2 Membrane Protein

SLC6A2, also named as norepinephrine transporter (NET), is mainly expressed in adrenal, placenta and testis. It can exert spatial and temporal control over the action of norepinephrine. The NET mediates the termination of neurotransmission via the reuptake of norepinephrine released into the extracellular milieu. Recent studies indicate that SLC6A2 variants are strongly associated with orthostatic intolerance. In addition, researches have confirmed several SLC6A2 SNPs could be potential therapeutic targets for psychiatric disorders, postural tachycardia, and play an important role in attention-deficit/hyperactivity disorder risk.

Fig.1 SLC6A2 mutations in myoclonic astatic epilepsy. (Jedlitschky, 2012)

Application of SLC6A2 Membrane Protein in Literature

1. Bi Y., et al. No association between SLC6A2, SLC6A3, DRD2 polymorphisms and schizophrenia in the Han Chinese population. Psychiatry Res. 2017, 253:398-400. PubMed ID: 28454051
   
   

   This article reports the association between the SLC6A2, SLC6A3, DRD2 polymorphisms and schizophrenia. These results indicate that no relationship is found in these three genes and schizophrenia in Han Chinese.

2. Verschure D.O., et al. Polymorphism of SLC6A2 gene does not influence outcome of myocardial ¹²³I-mIBG scintigraphy in patients with chronic heart failure. J Nucl Cardiol. 2018, 25(3):900-906. PubMed ID: 27844334
   
   

   This article analyzes the influence of SLC6A2 SNPs on myocardial ¹²³I-mIBG parameters in CHF. The data demonstrate that SLC6A2 gene polymorphism is not associated with any ¹²³I-mIBG derived parameters in this specific CHF population.

3. Luo J.W., et al. Methylation in promoter region of SLC6A2 gene in heart failure patients and its correlation with qi deficiency/blood stasis syndrome. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2015, 35(12), 1448-54. PubMed ID: 26882606
   
   

   Authors in this group analyze the expression and methylation levels of SLC6A2 in heart failure patients and examine the relationship between SLC6A2 and qi deficiency/blood stasis syndrome (QDS/BSS). The data show that the promoter abnormally methylation of SLC6A2 gene is one of the risk factors for HF and is related with QDS/BSS.

4. Yeh Y.W., et al. SLC6A2 variants may predict remission from major depression after venlafaxine treatment in Han Chinese population. J Psychiatr Res. 2015, 61:33-9. PubMed ID: 25512257
   
   

   This article focuses on the association between SLC6A2 gene polymorphisms and remission after venlafaxine treatment for major depressive disorder. The results suggest that SLC6A2 variants are strongly associated with treatment remission after venlafaxine in patients with MMD.

5. Pietrzak R.H, et al. Association of the rs2242446 polymorphism in the norepinephrine transporter gene SLC6A2 and anxious arousal symptoms of posttraumatic stress disorder. J Clin Psychiatry. 2015, 76(4):e537-8. PubMed ID: 25919853
   
   

   This article conducts a case-control study to examine the expression of SLC6A2 and the gene polymorphisms in patients who suffer from posttraumatic stress disorder. The data illustrate that the rs2242446 polymorphism of SLC6A2 gene has no effect on PTSD.

SLC6A2 Preparation Options

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Reference

1. Jedlitschky G, et al. (2012). Transporters in human platelets: physiologic function and impact for pharmacotherapy. Blood. 119(15), 3394-402.

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