SLCO3A1 Membrane Protein Introduction

Introduction of SLCO3A1

SLCO3A1, the official full name is solute carrier organic anion transporter family member 3A1 which owns 12 transmembrane domains. It is encoded by the SLCO3A1 gene in humans and belongs to the organic anion-transporting polypeptide family of membrane proteins. This gene is conserved in chimpanzee, cow, mouse, dog, rat, zebrafish, Rhesus monkey, chicken, and frog. 207 organisms have orthologs with this gene. SLCO3A1 is broadly expressed in lung, testis, and 23 other tissues, and is involved in sodium-independent transport of organic anions.

Basic Information of SLCO3A1
Protein Name	Solute carrier organic anion transporter family member 3A1
Gene Name	SLCO3A1
Aliases	OATP3A1, OATPD, SLC21A11
Organism	Homo sapiens (Human)
UniProt ID	Q9UIG8
Transmembrane Times	12
Length (aa)	705
Sequence	MQGKKPGGSSGGGRSGELQGDEAQRNKKKKKKVSCFSNIKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGALLSALPEFLTHQYKYEAGEIRWGAEGRDVCAANGSGGDEGPDPDLICRNRTATNMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMFGFPQSLPPHSEPAMESEQAMLSEREYERPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIILAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVPYGNSTAPGSALDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNSTNLTGCACLTTVPAENATVVPGKCPSPGCQEAFLTFLCVMCICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCLFWSTFCGEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNYKRYIKNHEGGLSTSEFFASTLTLDNLGRDPVPANQTHRTKFIYNLEDHEWCENMESVL

Function of SLCO3A1 Membrane Protein

SLCO3A1 is also known as SLC21A11 which belongs to the 12-membrane-spanning superfamily of solute carriers. SLCO3A1 mediates uptake of sodium-independent transport of organic anions, such as estrone-3-sulfate. SLCO3A1 also is involved in the transport of prostaglandins (PG) E1 and E2, deltorphin II, thyroxine (T4), vasopressin and BQ-123, while it’s not involved in the transport of DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), taurocholate, estrone-3-sulfate, DHEAS or digoxin. In addition, SLCO3A1 can transport bile acid efflux which can be upregulated as an adaptive response to cholestasis. SLCO3A1 is involved in drug-drug interactions through increasing uptake of simvastatin acid, and this could influence clinical outcomes. Moreover, SLCO3A1 is associated with Crohn’s disease via regulating NF-kB activity and intestinal perforation. Also, SLCO3A1 is associated with nicotine dependence through meta-analysis, and it’s also involved in the uptake of hormones during breast cancer development.

Fig.1 rs207959 T/C elevates SLCO3A1 mRNA and protein expression levels in colon and small intestine tissue of normal, non-CD diseases, and CD patients. (Wei, 2014)

Application of SLCO3A1 Membrane Protein in Literature

Pan Q., et al. Solute Carrier Organic Anion Transporter Family Member 3A1 is a Bile Acid Efflux Transporter in Cholestasis. Gastroenterology. 2018, pii: S0016-5085(18)34819-4. PubMed ID: 30063921

This article demonstrates that SLCO3A1 can transport bile acid efflux which can be upregulated as an adaptive response to cholestasis.
Atilano-Roque A. and Joy M.S. Characterization of simvastatin acid uptake by organic anion transporting polypeptide 3A1 (OATP3A1) and influence of drug-drug interaction. Toxicol In Vitro. 2017, 45(Pt 1): 158-165. PubMed ID: 28887287

This article indicates that SLCO3A1 is involved in drug-drug interactions by increasing uptake of simvastatin acid, and this could influence clinical outcomes.
Rawłuszko-Wieczorek A.A., et al. Effect of DNA methylation profile on OATP3A1 and OATP4A1 transcript levels in colorectal cancer. Biomed Pharmacother. 2015, 74: 233-42. PubMed ID: 26349991

This article shows the DNA methylation involved in OATP3A1 downregulation in colorectal carcinogenesis.
Wei S.C., et al. SLCO3A1, A novel Crohn's disease-associated gene, regulates NF-κB activity and associates with intestinal perforation. PLoS One. 2014, 9(6): e100515. PubMed ID: 24945726

This article shows that SLCO3A1 is associated with Crohn's disease by regulating NF-kB activity and intestinal perforation.
Wang K.S., et al. ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies. Drug Alcohol Depend. 2012, 124(3): 325-32. PubMed ID: 22377092

This article shows that SLCO3A1 is associated with nicotine dependence through meta-analysis, and this study provides potential insights into the pathogenesis of ND.

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Reference

Wei S C, et al. (2014). SLCO3A1, A novel Crohn's disease-associated gene, regulates nf-κB activity and associates with intestinal perforation. PLoS One. 9(6): e100515.

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