STX7 Membrane Protein Introduction

Introduction of STX7

STX7 is a protein that in humans is encoded by the STX7 gene. In melanocytic cells, STX7 gene expression may be regulated by MITF. STX7 is expressed in normal melanocytes, various benign melanocytic nevi, atypical nevi, and malignant melanoma. N-terminal regions of syntaxin 7, syntaxin 8, and vti1b contain well folded α-helical domains. Multidimensional NMR spectroscopy revealed that in syntaxin 7 and vti1b, the domains form three-helix bundles resembling those of syntaxin 1, Sso1p, and Vam3p.

Basic Information of STX7
Protein Name	Syntaxin-7
Gene Name	STX7
Aliases	/
Organism	Homo sapiens (Human)
UniProt ID	O15400
Transmembrane Times	1
Length (aa)	261
Sequence	MSYTPGVGGDPAQLAQRISSNIQKITQCSVEIQRTLNQLGTPQDSPELRQQLQQKQQYTNQLAKETDKYIKEFGSLPTTPSEQRQRKIQKDRLVAEFTTSLTNFQKVQRQAAEREKEFVARVRASSRVSGSFPEDSSKERNLVSWESQTQPQVQVQDEEITEDDLRLIHERESSIRQLEADIMDINEIFKDLGMMIHEQGDVIDSIEANVENAEVHVQQANQQLSRAADYQRKSRKTLCIIILILVIGVAIISLIIWGLNH

Function of STX7 Membrane Protein

The human syntaxin family consists of 15 proteins which are key molecules involved in the formation of transport vesicles in the exocytotic and endocytotic pathways. Published studies on the precise location of STX7 showed inconsistent results, where some studies suggested STX7 was associated with early endosomes, whereas others concluded that it resided in compartments within the late endosomal/lysosomal system. STX7 is required for the fusion of late endosomes with lysosomes, suggesting a role of STX7 as a regulator of membrane vesicular trafficking between late endosomes and lysosomes. STX7 has also been shown to be involved in the intracellular vacuolation process induced by the Helicobacter pylori-produced cytotoxin VacA in gastric epithelial cells. The expression level of STX7 protein is negatively related to tumor stage, suggesting that reduced expression of STX7 is associated with more aggressive tumors.

Fig.1 Structure of the STX7 protein.

Application of STX7 Membrane Protein in Literature

Wang L., et al. HCV-induced autophagosomes are generated via homotypic fusion of phagophores that mediate HCV RNA replication. PLoS Pathog. 2017, 13(9): e1006609. PubMed ID: 28931085

This research investigated the biogenesis pathway of HCV-induced autophagosomes. Results showed that HCV-induced phagocytes derived from the endoplasmic reticulum and underwent homotypic fusion to produce autophagosomes.
Bhat R., et al. An immunohistochemical survey of SNARE proteins shows distinct patterns of expression in hematolymphoid neoplasia. Am J Clin Pathol. 2016, 145(5): 604-616. PubMed ID: 27247366

This study suggested that STX7 is a potential marker for distinguishing between normal B precursors (hematogones) and B lymphoblasts.
Pattu V., et al. Syntaxin7 is required for lytic granule release from cytotoxic T lymphocytes. Traffic. 2011, 12(7): 890-901. PubMed ID: 21438968

Authors conducted this research is to investigate the role of Stx7 in the release of lytic granules from cytotoxic T lymphocytes (CTLs). Results showed that the accumulation of recycling TCRs at the immunological synapse was associated with Stx7.
Strömberg S., et al. Selective expression of Syntaxin-7 protein in benign melanocytes and malignant melanoma. J Proteome Res. 2009, 8(4): 1639-1646. PubMed ID: 19714869

This research implied that aggressive tumors were related to the reduced expression of STX7.
Achuthan A., et al. Regulation of the endosomal SNARE protein syntaxin 7 by colony-stimulating factor 1 in macrophages. Mol Cell Biol. 2008, 28(20): 6149-6159. PubMed ID: 18710945

This study indicated that Stx7 expression mediated by CSF-1 played a role in macrophage effector.

STX7 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-STX7 antibody development services.

Creative Biolabs' skillful scientists are glad to leverage our expertise and advanced technologies to help you with the membrane protein research. If you are interested, please feel free to contact us for more details.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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