TACR1 Membrane Protein Introduction

Introduction of TACR1

TACR1 (Tachykinin receptor1), also known as substance P (SP) receptor or NK-1 receptor, is encoded by TACR1 gene. It is a member of the G-protein-coupled receptor (GPCR) family, which consists of seven hydrophobic transmembrane (TM) domains with three extracellular and three intracellular loops, an amino-terminus, and a cytoplasmic carboxy-terminus. It’s commonly used to regulate local and systemic inflammatory processes, and many studies conducted in TACR1 reveal that it is a promising molecular diagnostic marker and novel therapeutic targets in the clinic.

Basic Information of TACR1
Protein Name	Tachykinin receptor 1
Gene Name	TACR1
Aliases	NK1R, TAC1R
Organism	Homo sapiens (Human)
UniProt ID	P25103
Transmembrane Times	7
Length (aa)	407
Sequence	MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS

Function of TACR1 Membrane Protein

The TACR1 receptor can be found in various immune cells, like gastrointestinal tracts, thyroid gland, and present in neurons. It preferentially binds to the SP, which indicates that plays an important role in many functions, such as, the stress and pain transmission signal, the contraction of smooth muscles and inflammation. The TACR1 receptor has also been studied in bipolar disorder, attention deficit hyperactivity disorder (ADHD), alcoholism and opioid addiction. Besides, many diseases also have been proved to be related to the TACR1 receptor (NK-1 receptor), including asthma, rheumatoid arthritis and gastrointestinal disorders. The TACR1 receptor antagonists have been applied to several pathophysiological models of anxiety and depression.

Fig.1 Structure of TACR1 membrane protein.

Application of TACR1 Membrane Protein in Literature

Bubak A.N., et al. Varicella Zoster Virus Induces Nuclear Translocation of the Neurokinin-1 Receptor, Promoting Lamellipodia Formation and Viral Spread in Spinal Astrocytes. The journals of infectious diseases. 2018, 218(8): 1324-1335. PubMed ID: 29788447

This article reports that the role of NK-1R in VZV-infected primary human spinal astrocytes (HA-sps) to shed light on the pathogenesis of VZV myelopathy.
Molinos-Quintana A., et al. Human acute myeloid leukemia cells express Neurokinin-1 receptor, which is involved in the antileukemic effect of Neurokinin-1 receptor antagonists. Investigational New Drugs. 2018, 1-10. PubMed ID: 29721755

This article reveals that how the substance P induced cell proliferation in both acute myeloid leukemia cell lines, and the function of four different Neurokinin-1 receptor antagonists in the potential treatment of human acute myeloid leukemia.
Warner S.C., et al. Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR1) gene. European journal of pain. 2017, 21(7): 1277-1284. PubMed ID: 28493529

Authors select six SNPs of Genotype data, which cover most variation in the TACR1 gene, to test for an association with symptomatic OA. Some sites are associated with a decreased risk of symptomatic OA.
Henssen A.G., et al. Targeting tachykinin receptors in neuroblastoma. Oncotarget. 2017, 8: 430-443. PubMed ID: 27888795

This article report that neuroblastoma cell lines can express TACR1 and this targeting TACR1 activity significantly reduces cell viability and finally induces apoptosis in neuroblastoma cell lines.
Sharp S.I., et al. Genetic association of the tachykinin receptor 1 TACR1 gene in bipolar disorder, attention deficit hyperactivity disorder, and the alcohol dependence syndrome. Am J Med Genet. 2014, 165(4): 373-380. PubMed ID: 24817687

Authors conducted a genome-wide association study in several case-control samples of BPAD, alcohol dependence syndrome (ADS) and attention-deficit hyperactivity disorder (ADHD). Several alleles which were founded in these diseases suggest a common molecular pathophysiology.

TACR1 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-TACR1 antibody development services.

As a forward-looking research institute as well as a leading customer service provider in the field of membrane protein, Creative Biolabs has won good reputation among our worldwide customers for successfully accomplishing numerous challenging projects including generation of many functional membrane proteins. Please feel free to contact us for more information.

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