Murine Leukemia Virus Vaccine

Creative Biolabs is a world leader in the field of vaccine development and can offer high-quality viral vaccines for use in prevention of viral infections. By consistently delivering the highest standards of quality, professionalism, and integrity, we want to become the partner of a choice for your requirements. With our extensive experience and advanced platform, we are therefore confident in offering the best vaccine development services against murine leukemia virus.

Murine Leukemia Virus Vaccine - Creative Biolabs

Murine leukemia viruses (MLVs) are group/type VI retroviruses named for their ability to cause cancer in murine hosts which belong to the Gammaretroviral genus of the Retroviridae family. The viral genome of these viruses is a single-stranded, linear, positive-sense RNA molecule and the genome contains gag, pol, and env regions, coding for structural proteins. They include both exogenous and endogenous viruses and among them, exogenous forms are transmitted as new infections from one host to another. In addition, there are several types of MLVs which are used in cancer research, namely Moloney, Rauscher, Abelson and Friend MLVs, respectively. The Friend murine leukemia virus (F-MLV) has been extensively used for both immunotherapy and vaccines.

Inactivated MLV Vaccine

The inactivated vaccine to protect against F-MLV infection was prepared by formalin or UV light inactivated. After vaccination in mice, the killed F-MLV particles were found to be incapable of synthesizing full-length viral DNA upon infection of a new host cell. The most important thing is that it can induce a strong and protective cytotoxic T cell (CTL)-mediated response to enhance the immunity in mice for against the virus infection.

Subunit MLV Vaccines

The membrane-proximal region of MLV envelope (Env) is a critical modulator of its functionality. Env proteins are known to exhibit immunosuppressive properties, which become apparent not only in retroviral infections but also in gene-based immunizations using retroviral immunogens, where envelope interferes with the induction of CD8+ T cell responses towards another, simultaneously or subsequently delivered, immunogen. Several subunit proteins can be used to form the vaccines against MLV, such as glycosylated gp70, exposed on the viral envelope and on the surface of virus-producing cells, p15E, an unglycosylated membrane polypeptide, attaches gp70 to the lipid bilayer of the cellular and viral membrane, and polypeptide p30, a gag gene product, which is the predominant protein of the inner core of these retroviruses.

For the vaccine strategy, a vaccine was designed by coupled gp70 to keyhole limpet haemocyanin (KLH) by glutaraldehyde and can save more than 90% of F-MLV infected mice from erythroleukaemia. Therefore, KLH may also be a suitable experimental carrier for subunits of gp70 or synthetic oligopeptides for viral vaccines. In addition, immunization with a plasmid encoding the F-MLV Leader-Gag protein resulted in induction of a strong specific CD8+ T cell response. Thus, more and more recombinant vaccinia virus for expressing either the gag or envelope proteins of the F-MLV helper virus have been shown to protect susceptible mice from F-MLV-induced erythroleukemia. These subunit proteins of MLV provide us more choices of vaccine design to protect against MLV infection.

Creative Biolabs is a highly proactive, robust, and diversified company with a strong, scientifically-proven background of viral vaccine development. We have experts who are able to help you with the vaccine development against murine leukemia virus. Our scientists are confident in offering the best services and products upon request!


All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.


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All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.

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