Recombinant Treponema Pallidum gatB Protein (aa 1-509) (strain Nichols) (VAng-Cr1519)

E. coli or Yeast or Baculovirus or Mammalian Cell.

Bacterial Antigens

ELISA, WB, SDS-PAGE, Immunogen, etc.

Tris-based buffer, 50% glycerol.

> 85% pure by SDS-PAGE.

Store at -20°C to -80°C.

Treponema Pallidum is a spirochaete bacterium with subspecies that cause the diseases syphilis, bejel, and yaws. It is a helically coiled microorganism which is about 6–15 µm long and 0.1–0.326 µm wide. The treponemes have a cytoplasmic and an outer membrane. Using light microscopy, treponemes are visible only by using dark field illumination. They are Gram negative, but some regard them as too thin to be Gram stained. This bacterium can be detected with special stains, such as the Dieterle stain. It is a motile spirochaete that is generally acquired by close sexual contact, entering the host via breaches in squamous or columnar epithelium. The organism can also be transmitted to a fetus by transplacental passage during the later stages of pregnancy, giving rise to congenital syphilis.

T. pallidum