Vaccines for Clostridium tetani
It is well known that tetanus has been a contagious and deadly disease for many years and is caused by the toxins produced by bacteria. The introduction of a tetanus toxoid vaccine has greatly reduced its incidence in developed and developing countries. Vaccination with bacterial toxoid vaccination and adjuvants is the best way to prevent the spread of this epidemic.
Clostridium tetani
Tetanus is an acute infectious disease caused by toxigenic strains of the bacterium Clostridium tetani (C. tetani). C. tetani is a Gram-positive, spore-forming, strictly anaerobic bacterium. Spores are ubiquitous in the environment, especially in warm and humid soils, and can be carried in the intestines tracts and feces of humans and animals. C. tetani enter the body through contaminated skin wounds or tissue damage, including those resulting from unclean deliveries, burns, surgery, and dental extractions, with a high mortality rate. The most important toxin of C. tetani is the highly potent tetanospasmin, which blocks inhibitory neurotransmitters in the central nervous system and causes the muscular rigidity and spasms typical of generalized tetanus.
Vaccines for Clostridium tetani
Tetanus vaccines are produced by the mechanism of inhibition tetanus toxin. The toxigenic strain of C. tetani grows in a liquid medium that favors toxin production, and the toxin produced therefrom is purified and then treated with formaldehyde to produce a toxoid antigen by inactivating the toxin. To increase immunogenicity, Tetanus toxoid (TT) is then formulated with aluminum or calcium salts and administered by intramuscular injection. Tetanus toxoid vaccines are produced in two forms, either as a single form of antigenic vaccine (TT) or in combination with diphtheria toxoid (DT), or mixed with diphtheria and whole cells or cellular pertussis (DTP).
The diphtheria-tetanus vaccine does not contain pertussis and can, therefore, be used in children who are intolerant of pertussis vaccine. Single-antigen tetanus toxoid vaccines containing only tetanus toxoid are usually not given to infants and children. Immunization against tetanus by vaccine alone is not enough, so it is necessary to immunize adults and adolescents by continuously using monovalent tetanus toxin as a booster dose to enhance immunity. Almost tetanus toxoids are combined with small amounts of other vaccines such as diphtheria DT or cell pertussis Tdap.
Our Services for Clostridium tetani Vaccines
- Formulating of immunization procedures
- Inactivation of toxins
- Suitable adjuvant
In order to meet the needs of customers, Creative Biolabs has built a team of experienced scientists with instruments and processes are specifically designed to provide the best service for any C. tetani vaccines. If you have any special needs in toxin vaccine or be interested in learning more about our services, please feel free to contact us for more details.
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
