Idiotype Specific Antibody Discovery Services

Overview Types of Anti-ID Abs Anti-ID Ab Development ServicesServices Highlight Case Study Applications

Anti-idiotype Antibodies (anti-ID Abs) Overview

Anti-ID Abs are Abs that can recognize the variable region of an Ab and produce specific binding. Anti-ID Abs play a vital role in the development of drugs. On the one hand, anti-ID Abs can serve as a valuable reference for immunogenicity analysis. On the other hand, they are also vital tools for pharmacokinetic/pharmacodynamics (PK/PD) studies. Creative Biolabs offers unparalleled anti-ID Abs production and downstream testing services. We are committed to developing anti-ID Abs with high specificity, high affinity and high sensitivity from different species, such as rabbit, chicken, cow, sheep, mice, rats and humans to meet your unique needs.

Fig.4 The structure of antibody. (Creative Biolabs Original)

Types of Anti-ID Abs


Antigen Blocking Type	Antigen Non-blocking Type	Drug-target Complex Specific Abs
Antigen binding: Inhibitory / neutralizing	Antigen binding: Non-inhibitory	Antigen binding: Non-inhibitory
Applications: Detection of free Ab drug and partially bound antibody drugs	Applications: Detection of total Ab drug	Applications: Detection of bound Ab drug only

Anti-ID Ab Development Summary

Services	Delivery	Lead time
Anti-ID Rabbit Polyclonal Ab Preparation Service	Purified Ab; Ab QC Report	3.5 months
Anti-ID Mouse Monoclonal Ab Preparation Service	Compete and/or non-compete purified Abs; Ab QC Report; Hybridoma cell line	5 months
Phage Displayed Library Screening of Anti-ID Ab	Purified Ab; Plasmid; Strain; Ab sequences, Ab QC Report	4 months
Development of Immunogenicity Detection Kits	Kit; Manual; R&D report	3.5 months
Development of PK Detection Kits	Kit; Manual; R&D report	3.5 months

Featured Anti-ID Ab Services

FREE Antibodies	Murine Anti-idiotypic Antibody
TOTAL Antibodies	Rabbit Anti-idiotypic Antibody
BOUND Antibodies	Chicken Anti-idiotypic Antibody
T Cell Receptors	Anti-idiotypic Antibody Production of BsAb
Single Domain Anti-idiotypic Antibody	Anti-idiotypic Antibody Production for ADA Assay
Anti-idiotypic Antibody Production for PK Assay

Featured Technology Platforms

Hybridoma Platform	Phage Display & Antibody Library	Polyclonal Antibody Development
Fig.8 Hybridoma platform. (Saeed, et al., 2017)	Fig.9 Phage display & antibody library. (Wu, et al., 2016)	Fig.10 Polyclonal antibody development. (Garcia-Calvo, et al.,2020)

Services Highlight

High-quality Abs
High specificity and sensitivity Abs against your targets of interest.
Fast turnaround time
The fastest production cycle is about 3.5 months.
Applicable to multiple drugs
Applicable drugs include but are not limited to: monoclonal antibody, polypeptide, protein, compound, cell line, DNA and so on.
One-stop service
Provide one-stop technical services, from antibody development to preclinical research of therapeutic Abs.
Customizable service
Provide customized experimental solutions according to your specific needs, saving you time and cost.

Case Study - Anti-ID antibody development

Case A

Ab Structure Analysis. (Creative Biolabs Original) Fig. 1 Anti-ID monoclonal Ab has no cross reaction with isotype human IgG and total human IgG.

Case B

Antigen blocking type. (Creative Biolabs Original) Fig. 2 Competition ELISA of Anti-ID monoclonal Ab.

Case C

Fig.3 Antigen non-blocking type. (Creative Biolabs Original) Fig. 3 Anti-ID polyclonal Ab-good specificity, little cross-reactivity with human IgG.

Applications

PK and PD Analysis of Ab Drugs	Immunogenicity study of Ab drugs	Preclinical research of therapeutic Abs
Controls in Ab blocking assays	Controls in ligand binding neutralizing assays	Suitable for high-throughput detection of specific Ab drug content in the blood

If you are interested in our anti- ID Ab production services, please contact us in time to get a detailed quotation.

References

Saeed, Abdullah FUH, et al. "Antibody engineering for pursuing a healthier future." Frontiers in microbiology (2017): 495.
Wu, Chien-Hsun, et al. "Advancement and applications of peptide phage display technology in biomedical science." Journal of biomedical science 23.1 (2016): 1-14.
Garcia-Calvo, Eduardo, et al. "From polyclonal sera to recombinant antibodies: A review of immunological detection of gluten in foodstuff." Foods 10.1 (2020): 66.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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