Custom Virus Like Particle (VLP) Production Services

Virus-like particles (VLPs) are artificial protein structures with a similar overall structure to their corresponding native viruses. They resemble viruses with self-assembly properties but lose their original infectious ability due to genome modifications. VLPs are symmetrically built from hundreds of coat proteins, which can be genetically engineered to present a regular arrangement of epitope chains on the desired positions of the outer surface. Compared with monomeric or oligomeric protein carriers, VLPs are able to provide not only a higher density of foreign proteins per particle but also support a distinctive three-dimensional conformation, which is especially important for the presentation of conformational epitopes. Currently, VLPs have been recognized as one of the most promising and extensively studied molecular carriers or nanoparticles, for a variety of applications.

VLP Production Systems

One crucial step for successful VLP production lies in the proper choice of appropriate expression host system. In general, the selection of an ideal system depends on many factors, e.g. the specific target, desired quantity, downstream applications, etc. Creative Biolabs has established a broad range of well-established expression platforms, which can meet diverse research and industrial objectives.

E. coli System	Yeast System	Insect Cell System	Mammalian Cell System	Plant System
The most commonly used system for VLP production with low cost, high yield, and rapid turnaround time.	It's capable of post-translational modifications like glycosylation or phosphorylation, and is free of endotoxin concerns.	It's another widely employed system for its fast growth, efficient post-translational modifications, and easy scaling-up.	It can both increase production flexibility and consistency and maximally recover the native eukaryotic PTMs.	It can decrease the risk of introducing human pathogens and are able to perform large-scale production at low cost.

Applications of VLPs

VLPs for Membrane Protein Expression

Our team now provides highly purified and stable VLPs containing a great variety of membrane proteins in the form of MP-VLPs to satisfy different demands such as ligand binding assays, antibody screening, and immunogen production.

VLPs for Vaccine Development

VLPs can serve as a perfect immunogen that can elicit highly potent immune responses in vivo. We have successfully raised many antibody binders using the VLP immunization strategy, particularly against viral antigens or membrane antigens. Our VLPs-based vaccine formulation is able to enhance the antigen immunogenicity remarkably by using adjuvant aluminum salts. Moreover, special methods will be employed to reduce preservative and VLP aggregation.

VLPs for Delivery System

Our team is able to apply VLPs as delivery systems to transport various compounds including DNA, siRNA, peptides, proteins, and drugs.

Bioimaging

Our team is professional in providing VLPs chemical modification services such as probe conjugation for bioimaging applications both in vivo and in vitro in virtue of VLPs' high biological compatibility.

Cell Targeting

We can develop sophisticated VLPs to enable highly specific cell targeting. Alternative approaches are available including vitamins, peptides, nucleic acids (aptamers), and carbohydrate proteins (mainly antibodies).

Cases of VLP Production

Creative Biolabs has made a long-term commitment to developing excellent-quality virus-like particle (VLP) products. Through years of study and expertise, our team has created various advanced systems for the manufacture, purification, and characterization of VLPs. With our excellent VLP products and services, we would be pleased to assist our clients anywhere in the world. We can currently provide the whole line of VLP goods, which includes, but is not limited to:

Creative Biolabs now offers state-of-the-art virus-like particle services and products based on our unparalleled technology platform. Our R&D team is made up of a group of self-inspired and experienced scientists, who are constantly devoted to providing the most professional and satisfactory assistance to our global customers. Please feel free to contact us for further discussions.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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