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NativeExtract™ Full-Length Membrane Protein (Super Nanodisc) Products

Introduction Advantages Applications Targets

Creative Biolabs is an outstanding service provider for membrane protein production, supporting the most comprehensive list of membrane protein products worldwide. Our scientists are working hard on the discovery of better membrane protein products to meet customer demands.

NativeExtract™ Membrane Protein Products

Membrane proteins (MPs) are necessary for energy synthesis, transport, signaling, and maintaining cell homeostasis. They are significant pharmacological targets since they are essential to both human health and normal function. Understanding how proteins work and are regulated in animals and cells requires an understanding of proteins in their natural environments. However, pure proteins under well-controlled settings provide a better place to study the atomic and molecular aspects of proteins' structures and processes. Working with pure proteins reconstituted in model membranes that are durable enough to support study in an abiotic environment for extended periods is necessary to fully comprehend MPs. In order to analyze the purified MP of interest's structure, function, and regulation, it must be placed into a membrane that allows it to function as it would in the native cell membrane while still being solubilized and stable.

Creative Biolabs has developed a proprietary synthetic compound to solubilize target membrane protein directly from cell membrane while retaining the native structure of the target protein. It dissolves cell membranes, similar to detergent, while using natural cellular phospholipids to form nanodiscs.

Schematic diagram of NativeExtract™ membrane protein products. (Creative Biolabs)Fig. 1 Schematic diagram of NativeExtract™ membrane protein products.

Advantages of NativeExtract™ Membrane Protein Products

Applications of NativeExtract™ Membrane Protein Products

Targets of NativeExtract™ Membrane Protein Products

Membrane proteins are important components of cells that perform a range of biological tasks that are necessary for organisms to survive. Membrane proteins make up a sizable portion of the human proteome and are the target of more than 60% of available drugs. Creative Biolabs offers membrane protein products to support the development of antibody and other therapeutics targeting membrane proteins. NativeExtract™ Membrane Protein Products in Creative Biolabs contain a series of GPCRs, including but not limited to these targets. If you're not satisfied with these products, please contact us for more information.

A B C DE FGHIKLMNOPQRSTUVX

A ABCB1ACKR1 ACKR2 ACKR3 ACKR4 ADCYAP1R1 ADGRA2 ADGRA3 ADGRB1 ADGRB2 ADGRB3 ADGRD1 ADGRE1 ADGRE2 ADGRE3 ADGRE5 ADGRF1 ADGRF2 ADGRF3 ADGRF4 ADGRF5 ADGRG1 ADGRG2 ADGRG3 ADGRG4 ADGRG5 ADGRG6 ADGRG7 ADGRL1 ADGRL2 ADGRL3 ADGRL4 ADGRV1 ADORA1 ADORA2A ADORA2B ADORA3 ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB2 ADRB3 AGTR1 AGTR2 APLNR AVPR1A AVPR1B AVPR2

B BDKRB1 BDKRB2 BRS3

C C3AR1 C5AR1 C5AR2 CALCR CALCRL CASR CAV1 CCKAR CCKBR CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CCRL2 CD151 CD36 CD37 CD47 CD63 CD81 CELSR1 CELSR2 CELSR3 CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CLDN18 CLDN2 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN9 CLPTM1 CMKLR1 CMTM6 CNR1 CNR2 CRHR1 CRHR2 CX3CR1 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CYSLTR1 CYSLTR2

D DRD1 DRD2 DRD3 DRD4 DRD5

E EDNRA EDNRB EMP2 ENTPD1 ENTPD2 ESYT1

F F2R F2RL1 F2RL2 F2RL3 FFAR1 FFAR2 FFAR3 FFAR4 FPR1 FPR2 FPR3 FSHR FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9

G GABBR1 GABBR2 GALR1 GALR2 GALR3 GCGR GHRHR GHSR GIPR GLP1R GLP2R GNRHR GPBAR1 GPER1 GPR1 GPR101 GPR107 GPR119 GPR12 GPR132 GPR135 GPR137 GPR139 GPR141 GPR142 GPR143 GPR146 GPR148 GPR149 GPR15 GPR150 GPR151 GPR152 GPR153 GPR156 GPR157 GPR158 GPR160 GPR161 GPR162 GPR17 GPR171 GPR173 GPR174 GPR176 GPR179 GPR18 GPR182 GPR183 GPR19 GPR20 GPR21 GPR22 GPR25 GPR26 GPR27 GPR3 GPR31 GPR32 GPR34 GPR35 GPR37 GPR37L1 GPR39 GPR4 GPR42 GPR45 GPR50 GPR52 GPR55 GPR6 GPR61 GPR62 GPR63 GPR65 GPR68 GPR75 GPR78 GPR82 GPR83 GPR84 GPR85 GPR87 GPR88 GPRC5A GPRC5B GPRC5C GPRC5D GPRC6A GRM1 GRM2 GRM3 GRM4 GRM5 GRM6 GRM7 GRM8 GRPR

H HCAR2 HCAR3 HCRTR1 HCRTR2 HRH1 HRH2 HRH3 HRH4 HTR1A HTR1B HTR1D HTR1E HTR1FHTR2A HTR2B HTR2C HTR4 HTR5A HTR6 HTR7

I ILDR2

K KCNK9 KISS1R

L LGR4 LGR5 LGR6 LHCGR LPAR1 LPAR2 LPAR3 LPAR4 LPAR5 LPAR6 LTB4R LTB4R2

M MAS1 MAS1L MC1R MC2R MC3R MC4R MC5R MCHR1 MCHR2 MFSD13AMLC1 MLNR MRGPRD MRGPRE MRGPRX1 MRGPRX2 MRGPRX3 MRGPRX4 MS4A1 MTNR1A MTNR1B

N NMBR NMUR1 NMUR2 NPBWR1 NPBWR2 NPC1L1 NPFFR1 NPFFR2 NPSR1 NPY1R NPY2R NPY5R NTSR1 NTSR2

O OPN1SW OPN3 OPN4 OPN5 OPRD1 OPRK1 OPRL1 OPRM1 OR10A2 OR10A4 OR10A5 OR10H1 OR10H2 OR10H3 OR10J1 OR11A1 OR12D3 OR1A1 OR1A2 OR1D2 OR1D5 OR1E1 OR1E2 OR1F1 OR1G1 OR2A4 OR2B2 OR2B3 OR2C1 OR2D2 OR2F1 OR2H1 OR2H2 OR2J2 OR2M4 OR2S2 OR2W1 OR3A1 OR3A2 OR3A3 OR51B2 OR51B4 OR51E1 OR51E2 OR52D1 OR5I1 OR5V1 OR6A2 OR7A17 OR7A5 OR7C2 OR8B8 OR8D2 OR8G2P OR8U8 OXER1 OXGR1 OXTR

P P2RX7 P2RY1 P2RY10 P2RY11 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY6 P2RY8 PLA2R1 PRLHR PROKR1 PROKR2 PROM1 PTAFR PTGDR PTGDR2 PTGER1 PTGER2 PTGER3 PTGER4 PTGFR PTGIR PTH1R PTH2R PVRIG

Q QRFPR

R RHO RRH RXFP1 RXFP2 RXFP3 RXFP4

S S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SCARB1 SCTR SLC1A5 SLC25A4 SLC2A12 SLC2A4 SLC39A6 SLC4A7 SLC7A11 SMO SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 STEAP1 STEAP2 STING1 SUCNR1

T TAAR1 TAAR2 TAAR5 TAAR6 TAAR8 TAAR9 TACR1 TACR2 TACR3 TAS1R1 TAS1R2 TAS1R3 TAS2R1 TAS2R16 TAS2R3 TAS2R38 TAS2R4 TAS2R5 TAS2R60 TAS2R9 TBXA2R TLR2 TLR4 TLR5 TLR7 TLR9 TM4SF1 TMCC3 TPRA1 TRHR TRPA1 TRPV1 TSHR TSPAN33 TSPAN8

U UTS2R

V VIPR1 VIPR2 VN1R1

X XCR1

All listed customized services & products are for research use only, not intended for pharmaceutical, diagnostic, therapeutic or any in vivo human use.

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