In most cases, membrane proteins are purified through recombinant methods and extracted using detergents to produce the proteins solubilized in detergent micelles. While detergents are the most common agents used for membrane proteins extraction, detergent addition strips the protein of its native lipid environment and thus membrane proteins' stability and structure are compromised. Polymers offer a membrane proteins platform of excellent properties. Polymer-encased nanodiscs support functional membrane proteins and address some of the limitations present in other membrane proteins reconstitution platforms.
An alternative option to achieve a more stabilizing environment for membrane proteins is the replacement of detergent by amphiphiles. This class of amphipathic polymers comprises a polyacrylate backbone that is equipped with pendant hydrophobic and hydrophilic sidechains. Amphipols provide a versatile platform for membrane proteins since they significantly improve the stability of membrane proteins.
Cat | Product Name | Molecular Formula | Formula Weight |
MPP010K | Amphipol A8-35 | C6.2H10.3O1.35N0.65Na0.35)~72 | 9 kDa |
MPP011K | Poly (Maleic Anhydride-alt-1-Decene) substituted with 3-(Dimethylamino) Propylamine | (C19H36O3N2)n | 18,500.00 |
MPP012K | Poly (Maleic Anhydride-alt-1-Tetradecene) substituted with 3-(Dimethylamino) Propylamine | (C23H44O3N2)n | 12,000.00 |
MPP013K | Poly (Maleic Anhydride-Alt-1-Octadecene) substituted with 3-(Dimethylamino) Propylamine | (C27H52O3N2)n | 39,000-65,000 |
MPP014K | Biotinylated Amphipol A8-35 | C6.5H11.225O1.375N0.75Na0.325)~72 | 9.3 kDa |
MPP015K | Poly (Maleic Anhydride-alt-1-Decene) substituted with 3-(Dimethylamino) Propylamine and Biotin ethylene diamine | (C19H36O3N2)n.(C26H43O5N4S)m | 18.5 kDa |
MPP016K | Non-Ionic Amphipol A8-35 | C7H15O4SN (C31H54O15N2)n | 7000-35000g/mol |
All listed customized services & products are for research use only, not intended for pharmaceutical, diagnostic, therapeutic or any in vivo human use.