Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsCreative Biolabs stands as a prominent authority proficient in harnessing hybridoma technology for the advancement of monoclonal antibody (mAb) development. Leveraging our wealth of expertise and cutting-edge framework, we take pride in extending hybridoma solutions across various species to cater to a global clientele.
Hybridoma technology, a time-honored approach for the sustained production of mAb on a large scale, involves the fusion of specific antibody-producing B lymphoblasts with myeloma cells, culminating in the generation of hybrid cell lines pivotal to this technique. The process typically commences with animal immunization, followed by the isolation of splenocytes, from which B cells generating target-specific antibodies are extracted and subsequently fused with myeloma cells. These resultant stable hybridoma cells exhibit the capacity for continuous expression of antigen-specific mAbs. These mAbs hold significant value not only in fundamental research within the realms of biology and immunology but also in diverse medical contexts. Furthermore, bolstered by supplementary advanced methodologies offered at Creative Biolabs, such as hybridoma sequencing, anti-idiotype Antibody production, and antibody-drug conjugates (ADCs), the expanded utilization of mAbs can significantly contribute to the development of therapeutic or diagnostic modalities.
Fig.1 Hybridoma technology.
Our team of researchers possesses vast expertise in managing diverse antigen variants. We are proficient in utilizing either purified antigens or commencing with in silico sequences provided by our clients. Leveraging our state-of-the-art recombinant/synthetic systems, we can generate soluble proteins and peptides. Additionally, through our innovative Magic™ membrane protein production services, Creative Biolabs offers the capability to produce membrane proteins in a variety of formats tailored to the specific needs of our clientele. We also provide comprehensive Services for Immunogen Design, ensuring a tailored approach to meet your specific needs.
In response to the unique project requisites of our clientele, we offer customized immunization strategies, encompassing a range of approaches such as DNA immunization, whole cell immunization, and various conventional immunization techniques.
Tailored to the specifications of our clients, antibody preparation and refinement, whether achieved in vivo or in vitro, will be meticulously executed. Delivery of top-tier antibodies of exceptional quality is assured.
Sequencing (covering variable regions: VH and VL) and report (both DNA and amino acid sequences, with CDR regions highlighted).
90-120 days. The time may vary depending on the different requirements, and additional time should be allowed for additional validation testing or repetition, if necessary.
As a highly optimized service, our liposome immunization technology relies on a proprietary liposome immunization procedure using liposome-encapsulated antigens, which including but not limited to the polysaccharide, lipid, glycolipid, and DNA.
Our proprietary mouse immunization approach allows us to provide mouse monoclonal antibodies within 70 days.
We have developed a proprietary hybridoma-generation platform for efficient development of high-affinity and high-specificity rat monoclonal antibodies.
We have extensive experience in producing monoclonal antibodies in hamsters.
Through fusing with our specific myeloma as partner, guinea pig hybridoma can be developed with excellent stability and productivity.
The immunization of "knock-out" mice was an effective way to overcome the problem of inter-species sequence similarity in antibody production.
We provide custom anti-small molecule mAb development services through hybridoma technology.
It is important to determine the application and hybridoma screening method since not all antibodies will work with every application.
We now have the capability and technology platforms to offer you diverse hybridoma rescue services.
Immunogen design service is one of our core technical services. We offer complementary protein expression or peptide design services to generate custom antibodies with better performance.
Delivering the final products with fast turnaround time and high quality.
We provide world-class packaging services for hybridoma isotype Identification and switching.
Fig.2 Application of hybridoma services.
The advent of hybridoma technology has transformed medical diagnostics, furnishing exceptionally precise mAb tailored for diverse assays. Employed in methodologies like ELISA, immunofluorescence, and Western blotting, these antibodies facilitate the identification of targeted proteins or pathogens within clinical specimens. This level of precision is crucial for facilitating early and accurate disease detection.
MAbs synthesized via hybridoma technology have emerged as indispensable components of therapeutic modalities. Whether addressing breast cancer or lymphoma, these antibodies are meticulously engineered to selectively target disease-associated molecules. The outcome is a therapeutic strategy characterized by minimized adverse effects and optimized efficacy.
Hybridoma technology has propelled fundamental inquiries in immunological, cellular, and associated disciplines. MAbs, serving as indispensable instruments, expedite the examination of distinct proteins, thereby elucidating cellular phenomena and unraveling the molecular intricacies inherent to diverse diseases.
The client provided a protein target X, we designed a peptide immunogen and did the function test of selected positive hybridoma. Fig.2 is the ELISA titration result in the immunization process. Fig.3 is the ELISA result of the finally selected hybridomas.
As an industrial leader specializing in custom services, Creative Biolabs also provides gene-engineered antibodies including single-domain antibodies and humanized antibodies. Moreover, we can conduct phage display antibody library screening and antibody development by the single B cell sorting platform. Should you express interest in our offerings, we warmly encourage you to reach out for further elucidation.
Use the resources in our library to help you understand your options and make critical decisions for your study.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
