Premade Library based Binder Discovery Services

Premade Libraries Screening Services Approaches Advantages Cases

Creative Biolabs has constructed a variety of peptide and antibody libraries. These premade libraries accelerate the process of developing peptide and antibody detection reagents and drugs for our customers.

Premade Libraries

With years of experience in molecular biology operations and primer design, Creative Biolabs has built various high-quality libraries of multiple species and fragment types. We can use these libraries to provide screening services to our customers or license some of these libraries as products.

Fig. 1 A figure to show different formats of antibody fragments. (Creative Biolabs Original)

Antibody Libraries

HumanMouseRabbitChicken V_HH (Camel, Llama, Alpaca) Humanized V_HH

Antibody Library ID	Display Technology	Library Format	Library Size
HuScL-6	pIII-fusion, Phagemid Phage Display	Naïve scFv	2.1×10¹¹
HuScL-7	pIII-fusion, Phagemid Phage Display	Naïve scFv	1.1×10¹⁰
HuScL-3S	pIII-fusion, Phagemid Phage Display	Semi-synthetic scFv	>1.0×10¹¹
HuFabL-4	pIII-fusion, Phagemid Phage Display	Naïve Fab	1.9×10¹⁰
HuFabL-5	pIII-fusion, Phagemid Phage Display	Naïve Fab	1.1×10¹⁰
HuFabssL-1	pIII-fusion, Phagemid Phage Display	Naïve & synthetic Fab	1.8×10¹⁰
HuscL-YDP-3	Yeast Display	Naïve scFv	1.9×108

Antibody Library ID	Display Technology	Library Format	Library Size
MuScL-2	pIII-fusion, Phagemid Phage Display	Naïve scFv	5.3×10¹⁰
MuFabL-2	pIII-fusion, Phagemid Phage Display	Naïve Fab	1.2×10¹⁰

Antibody Library ID	Display Technology	Library Format	Library Size
RaFabL-1	pIII-fusion, Phagemid Phage Display	Naïve Fab	7.5×10⁹
RaFabL-2	pIII-fusion, Phagemid Phage Display	Naïve Fab	1.2×10¹⁰

Antibody Library ID	Display Technology	Library Format	Library Size
Chicken-ScL-2	pIII-fusion, Phagemid Phage Display	Naïve scFv	1.1×10¹⁰

Antibody Library ID	Display Technology	Library Format	Library Size
CaV_HHL-4	pIII-fusion, Phagemid Phage Display	Naïve V_HH	2.63×10¹⁰
CaV_HHL-5	pIII-fusion, Phagemid Phage Display	Naïve V_HH	3.0×10¹⁰
CaV_HHL-6	pIII-fusion, Phagemid Phage Display	Naïve V_HH	2.43×10⁹
LlaV_HHL-1	pIII-fusion, Phagemid Phage Display	Naïve V_HH	2.0×10⁹
LlaV_HHL-2	pIII-fusion, Phagemid Phage Display	Naïve V_HH	1.8×10¹⁰
AlV_HHL-1	pIII-fusion, Phagemid Phage Display	Naïve V_HH	1.35×10¹⁰
AlV_HHL-2	pIII-fusion, Phagemid Phage Display	Naïve V_HH	1.5×10¹¹
LlaV_HHL-S1	pIII-fusion, Phagemid Phage Display	Synthetic V_HH	1.5×10¹¹
CaV_HHL-S2	pIII-fusion, Phagemid Phage Display	Synthetic V_HH	5.4×10¹⁰
CaV_HHL-S3	pIII-fusion, Phagemid Phage Display	Synthetic V_HH	2.2×10¹⁰
CaV_HHL-S4	pIII-fusion, Phagemid Phage Display	Semi-synthetic V_HH	5.3×10¹⁰

Antibody Library ID	Display Technology	Library Format	Library Size
HuV_HHL-S1	pIII-fusion, Phagemid Phage Display	Synthetic V_HH	>1.0×10¹¹
HuV_HHL-S2	pIII-fusion, Phagemid Phage Display	Semi-synthetic V_HH	>1.0×10¹⁰

Peptide Libraries

LinearCyclicOthers

Peptide Library ID	Phage Display	Library Format	Library Size
TriCo-16	pIII-fusion, True Phage Display	16-mer peptide library	1.1×10¹⁰
TriCo-20	pIII-fusion, True Phage Display	20-mer peptide library	1.3×10¹⁰

Peptide Library ID	Phage Display	Library Format	Library Size
TriCo-C9	pIII-fusion, Phagemid Phage Display	Cyclic 9-mer peptide library	1.10×10¹⁰
TriCo-C9L	pIII-fusion, Phagemid Phage Display	Cyclic 9-mer peptide library	6.8×10¹⁰

Peptide Library ID	Phage Display	Library Format	Library Size
Protease-10A	pIII-fusion, Phagemid Phage Display	HiAffi tagged 10 mer peptide library	1.10×10¹⁰

Premade Library based Screening Services

The high-quality premade libraries constructed by Creative Biolabs facilitate the discovery of peptide and antibody drugs. We can provide premade library screening services for different target types, such as peptides, proteins, and cells. In addition, thanks to many years of screening experience and multiple screening strategies, we can offer peptide and antibody drug development services targeting precise epitopes, such as receptor and ligand binding epitopes, TCR-like epitopes, and idiotypic epitopes. These screened binders are suitable for a variety of immunotherapies, such as CAR-T, bifunctional antibodies, ADC, and immune checkpoints.

Premade Antibody Library Screening Services

Functional Human Antibody Discovery
Various types of premade human antibody libraries
Diverse genetic materials, high diversity libraries
Large library capacity, >2.1x10¹¹
High affinity, from 10-7 to 10-9 M

Anti-Peptide/Protein Antibody Discovery
For purified proteins, protein segments, synthetic peptide, Toxic proteins, poorly immunogenic proteins

Anti-Cell-Based Target Antibody Discovery
For anti-membrane protein antibody discovery, such as GPCRs, transporter Proteins, and ion channel proteins.
For Cell internalization antibody screening

Bifunctional Antibodies Discovery
Various types of premade libraries suitable for a variety of targets

Anti-Epitope Antibody Discovery
TCR-like antibody
Anti-idiotype antibody discovery
Anti-PTM antibody
Receptor and ligand binding epitope antibodies

Premade Peptide Library Screening Service

Screening Approaches

With decades of experience, scientists at Creative Biolabs specialize in library screening projects. We have established a variety of screening strategies to achieve customized goals best:

Advantages of Premade Library

Compared to other approaches, premade libraries offer several advantages:

Time Efficiency - Creative Biolabs provides customers with a rich selection of ready-to-use premade libraries. It saves time on sample collection and library construction. This speeds up the development process of ideal binders and allows you to focus more on the unique aspects of your application.

High Quality & Reliability – Creative Biolabs can construct large-capacity and high-diversity libraries and conduct strict quality control and batch management on the libraries, thereby improving the screening success rate.

Cost-Effectiveness - Using premade libraries can reduce the cost of building libraries, thereby reducing development costs.

Species Suitability - Human-derived premade antibody library avoids the subsequent humanization process. And the antibodies obtained from the naïve antibody library have good developability.

Cases

Case 1- Internalization Antibody Discovery from a Premade Phage Display Human Antibody Library

Fig. 2 A FACS data indicates an internalization antibody discovered from a premade phage display human antibody library was observed to internalize into both human and mouse target cells specifically. (Creative Biolabs Original)

Results

The selected candidate antibody from a premade human antibody library was observed to internalize into both human and mouse target cells specifically, indicating that the discovery of internalization antibody was successful.

Case 2 - Premade Antibody Library Screening for MHC-Peptide Complex

Fig. 3 A ELISA data shows there are 7 unique clones identified from premade libarary to recognize the target MHC-peptide positively. (Creative Biolabs Original)

Results

7 unique clones were identified to recognize the target MHC-peptide positively.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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