The complement system is an important component of innate immunity, playing a key role in defending against invading pathogens. It consists of approximately 60 soluble and membrane-bound proteins, including core components, receptors,Read More…
A New Theory of Immune Complement-Mediated Synaptic Loss in Alzheimer’s Disease
The immune complement system is a crucial component of the body’s intrinsic immunity, playing roles such as regulating immune responses and clearing pathogens. A growing body of research suggests that the complement system is aberrantlyRead More…
Aging Promotes a Functional Shift in C1q Secreted by Microglia
Microglia-neuron interactions regulate brain development, maturation, homeostasis, and disease genesis. The innate immune complement component C1q, produced and secreted by microglia, has brain function specificity. C1q acts as an initiating molecule forRead More…
Intestinal Complement System Can Coexist with Symbiotic Bacteria and Resist Pathogens
The complement system is a primary barrier of the innate immune defense system formed by a series of proteins working in a highly coordinated manner to defend against microbial invasion of host tissues. InRead More…
The Battle Between Tumors and Complement
The complement system, as an important component of the body’s immune system, plays a key role in tumor development and therapy. Tumor immunomodulation by the complement system has a dual role inRead More…
Complement Receptor Protein CD35
CD35, also known as complement receptor 1 (CR1), plays a crucial role in the complement system. The complement system is part of the immune system that recognizes and removes pathogens, promotes inflammatoryRead More…
Complement Bomb – Complement Negative Regulatory Factor H
Structure of Complement Regulatory Protein Factor H Complement Factor H, also known as Factor H and CFH, is a sialic acid-containing glycoprotein that plays an integral role in regulating the complement-mediated immuneRead More…
Complement Therapy Newcomer: Dianthus Therapeutics
Dianthus Therapeutics’ (DNTH) primary asset is DNTH103, a selective monoclonal antibody targeting the active form of complement C1s. The main focus is a me-better version of Sanofi’s already-marketed C1s monoclonal antibody, Sutimlimab.Read More…
Specific Discussions of the Molecular Mechanisms of Complement Receptors
Cascade activation of the complement system is one of the key mechanisms of the immune system against pathogenic infections. It is a complex network of plasma proteins, including inflammatory peptides, proteases, andRead More…
Structurally Revealing the Coupled Mechanism of Complement Receptor Activation and Signal Transduction
The complement system plays a crucial role in the body’s defense against harmful invaders. It is an essential component of the innate immune response, and its end products, C3a and C5a, exertRead More…