Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (Fab-scFv-Fc) (FABVC-086)

Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CD3 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-gpA33 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can retarget T cells to tumor cells. It is designed for the research of Non-Hodgkin's lymphoma (NHL) therapy.

Datasheet INQUIRY

Specifications

Targets

CD3 & gpA33

Type

Fab-Fc Fusion Proteins

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Non-Hodgkin's lymphoma (NHL)

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

Target 2

gpA33

Gene ID

10223

UniProt ID

Q99795

Alternative Names

GPA33; glycoprotein A33; glycoprotein A33 (transmembrane); A33; cell surface A33 antigen; transmembrane glycoprotein A33

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (Fab-scFv-Fc) (CAT#: FABVC-086)

Specifications

Targets

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