At the early stage of BsAb development, somatic hybridization of two hybridomas were widely used. BsAbs created by hybrid-hybridoma are mainly IgG-like molecules, which generally have longer serum half-lives than bispecific fragments, and maintain Fc-mediated effector functions, including antibody-dependent cellular phagocytosis (ADCP), antibody-dependent cell-mediated cytotoxicity (ADCC), as well as complement-dependent cytotoxicity (CDC).
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