Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Minibody) (MiniB-165)

Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Minibody) is designed to be expressed as the anti-HER1 scFv fused to N-terminus of Knob-CH3 domain and the anti-HER3 scFv to the Hole-CH3 domain, or vice versa. The CH3 domains are further stabilized by C-terminal disulfide bonds. This BsAb can bind and inactivate two receptors simultaneously. It is designed for the research of Head and neck cancer; Colorectal cancer therapy.

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Specifications

Targets

HER1 & HER3

Type

Minibody

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Head and neck cancer; Colorectal cancer

Targets

Target 1

HER1

Gene ID

1956

UniProt ID

P00533

Alternative Names

EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog

Target 2

HER3

Gene ID

2065

UniProt ID

P21860

Alternative Names

ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor 3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-HER1 x Anti-HER3 Bispecific Antibody (Minibody) (CAT#: MiniB-165)

Specifications

Targets

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