Recombinant Human Anti-VEGFR1 x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) (SCTB-H177)

Recombinant Anti-VEGFR1 x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) is designed to be expressed as a single chain with three scFv units, two distal binding sites for VEGFR1 and a central site for CD3. It contains a His-tag at the C/N terminus for affinity purification. This BsAb can retarget T cells to tumor cells. It is designed for the research of Colon cancer; Rectal cancer therapy.

Datasheet INQUIRY

Specifications

Targets

CD3 & VEGFR1

Type

Single-chain Triplebody

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Colon cancer; Rectal cancer

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3 (Cluster of differentiation 3), originally known as T3, is one of the first groups of human T lymphocyte surface antigens recognized by monoclonal antibodies. It has been reported that antibodies against CD3 could either stimulate T cells to divide or inhibit the progress of effector functions according to the conditions used. It plays an important role in T cell and the CD3 T-cell co-receptor helps to activate the cytotoxic T-Cell and T helper cells. The CD3 molecule is composed of a protein complex and consists of four distinct chains. The complex of mammals contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. All these chains associate with T-cell receptor and the ζ-chain to generate an activation signal in T lymphocytes.

Target 2

VEGFR1

Gene ID

2321

UniProt ID

P17948

Alternative Names

FLT1; fms-related tyrosine kinase 1; FLT; FLT-1; VEGFR1; VEGFR-1; vascular endothelial growth factor receptor 1; fms-like tyrosine kinase 1; tyrosine-protein kinase FRT; tyrosine-protein kinase receptor FLT; vascular permeability factor receptor; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

Online Inquiry

Customer Reviews and Q&As

There are currently no customer reviews or questions for Recombinant Human Anti-VEGFR1 x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) (SCTB-H177). Click the button below to contact us or submit your feedback about this product.

Recombinant Human Anti-VEGFR1 x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) (CAT#: SCTB-H177)

Specifications

Targets

Customer Reviews and Q&As