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Ad Fiber Knob & CEA Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Target 2 INQUIRY
T-BSDB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Tandem Diabody) Human Ad Fiber Knob CEA Inquiry
SCIGG-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (scIgG) Human Single chain IgGs Ad Fiber Knob CEA Inquiry
FVTIG-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (scFv4-Ig) Human Appended IgGs Ad Fiber Knob CEA Inquiry
BSSG-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (scFv-IgG) Human Appended IgGs Ad Fiber Knob CEA Inquiry
IGLFV-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (IgG(L)-scFv) Human Appended IgGs Ad Fiber Knob CEA Inquiry
BSGV-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (IgG-Fv) Human IgG-Fv Ad Fiber Knob CEA Inquiry
BSDG-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Fv-IgG) Human Appended IgGs Ad Fiber Knob CEA Inquiry
BABFV-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins Ad Fiber Knob CEA Inquiry
FABVC-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins Ad Fiber Knob CEA Inquiry
SCDBC-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob CEA Inquiry
BSDBC-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob CEA Inquiry
SCDBF-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob CEA Inquiry
BSFVF-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob CEA Inquiry
BSDBF-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob CEA Inquiry
BSTF-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv Ad Fiber Knob CEA Inquiry
BSCFV-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (scFv-Fc) Human scFv-Fc Ad Fiber Knob CEA Inquiry
MNAB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Miniantibody) Human Miniantibody Ad Fiber Knob CEA Inquiry
BSFC-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (scFv-CH3) Human scFv-CH3 Ad Fiber Knob CEA Inquiry
BSCC-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL Ad Fiber Knob CEA Inquiry
BIBD-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Bibody) Human Bibody Ad Fiber Knob CEA Inquiry
FABFV-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Fab-Fv) Human Fab-Fv Ad Fiber Knob CEA Inquiry
MiniB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Minibody) Human Minibody Ad Fiber Knob CEA Inquiry
SCDB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Ad Fiber Knob CEA Inquiry
FABIG-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Fab-IgG) Human Fab-IgG Ad Fiber Knob CEA Inquiry
TRIB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Triple Body) Human Triple Body Ad Fiber Knob CEA Inquiry
BSIG-003 Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (IgG-IgG) Human IgG-IgG Ad Fiber Knob CEA Inquiry
CROSSAB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (CrossMab) Human CrossMab Ad Fiber Knob CEA Inquiry
IGFV-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (IgG-scFv) Human IgG-scFv Ad Fiber Knob CEA Inquiry
BSDB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Diabody) Human Diabody Ad Fiber Knob CEA Inquiry
BSFAB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Tandem Fab) Human Tandem Fab Ad Fiber Knob CEA Inquiry
BSFV-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Tandem scFv) Human Tandem scFv Ad Fiber Knob CEA Inquiry
FABIG-138 Recombinant Anti-CEA x Anti-GD2 Bispecific Antibody (Fab-IgG) Human Fab-IgG CEA GD2 Inquiry
FABIG-137 Recombinant Anti-CEA x Anti-DTPA Bispecific Antibody (Fab-IgG) Human Fab-IgG CEA DTPA Inquiry
FABIG-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Fab-IgG) Human Fab-IgG CEA DR5 Inquiry
FABIG-072 Recombinant Anti-CD3 x Anti-CEA Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 CEA Inquiry
FABIG-010 Recombinant Anti-AP (Alkaline Phosphatase) x Anti-CEA Bispecific Antibody (Fab-IgG) Human Fab-IgG AP (Alkaline Phosphatase) CEA Inquiry
FABIG-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Fab-IgG) Human Fab-IgG Ad Fiber Knob ITGAV Inquiry
FABIG-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Fab-IgG) Human Fab-IgG Ad Fiber Knob EPCAM Inquiry
FABIG-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Fab-IgG) Human Fab-IgG Ad Fiber Knob CD40 Inquiry
TRIB-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Triple Body) Human Triple Body CEA TNFα Inquiry
TRIB-141 Recombinant Anti-CEA x Anti-nido-Carboranes Bispecific Antibody (Triple Body) Human Triple Body CEA nido-Carboranes Inquiry
TRIB-140 Recombinant Anti-CEA x Anti-HSG Bispecific Antibody (Triple Body) Human Triple Body CEA HSG Inquiry
TRIB-139 Recombinant Anti-CEA x Anti-GZ (β-galactosidase) Bispecific Antibody (Triple Body) Human Triple Body CEA GZ (β-galactosidase) Inquiry
TRIB-138 Recombinant Anti-CEA x Anti-GD2 Bispecific Antibody (Triple Body) Human Triple Body CEA GD2 Inquiry
TRIB-137 Recombinant Anti-CEA x Anti-DTPA Bispecific Antibody (Triple Body) Human Triple Body CEA DTPA Inquiry
TRIB-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Triple Body) Human Triple Body CEA DR5 Inquiry
TRIB-072 Recombinant Anti-CD3 x Anti-CEA Bispecific Antibody (Triple Body) Human Triple Body CD3 CEA Inquiry
TRIB-010 Recombinant Anti-AP (Alkaline Phosphatase) x Anti-CEA Bispecific Antibody (Triple Body) Human Triple Body AP (Alkaline Phosphatase) CEA Inquiry
TRIB-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Triple Body) Human Triple Body Ad Fiber Knob ITGAV Inquiry
TRIB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Triple Body) Human Triple Body Ad Fiber Knob EPCAM Inquiry
TRIB-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Triple Body) Human Triple Body Ad Fiber Knob CD40 Inquiry
BSIG-142 Anti-CEA x Anti-TNFα Bispecific Antibody (IgG-IgG) Human IgG-IgG CEA TNFα Inquiry
BSIG-141 Anti-CEA x Anti-nido-Carboranes Bispecific Antibody (IgG-IgG) Human IgG-IgG CEA nido-Carboranes Inquiry
BSIG-140 Anti-CEA x Anti-HSG Bispecific Antibody (IgG-IgG) Human IgG-IgG CEA HSG Inquiry
BSIG-139 Anti-CEA x Anti-GZ (β-galactosidase) Bispecific Antibody (IgG-IgG) Human IgG-IgG CEA GZ (β-galactosidase) Inquiry
BSIG-138 Anti-CEA x Anti-GD2 Bispecific Antibody (IgG-IgG) Human IgG-IgG CEA GD2 Inquiry
BSIG-137 Anti-CEA x Anti-DTPA Bispecific Antibody (IgG-IgG) Human IgG-IgG CEA DTPA Inquiry
BSIG-136 Anti-CEA x Anti-DR5 Bispecific Antibody (IgG-IgG) Human IgG-IgG CEA DR5 Inquiry
BSIG-072 Anti-CD3 x Anti-CEA Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 CEA Inquiry
BSIG-010 Anti-AP (Alkaline Phosphatase) x Anti-CEA Bispecific Antibody (IgG-IgG) Human IgG-IgG AP (Alkaline Phosphatase) CEA Inquiry
BSIG-005 Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (IgG-IgG) Human IgG-IgG Ad Fiber Knob ITGAV Inquiry
BSIG-004 Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (IgG-IgG) Human IgG-IgG Ad Fiber Knob EPCAM Inquiry
BSIG-002 Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (IgG-IgG) Human IgG-IgG Ad Fiber Knob CD40 Inquiry
CROSSAB-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (CrossMab) Human CrossMab CEA TNFα Inquiry
CROSSAB-141 Recombinant Anti-CEA x Anti-nido-Carboranes Bispecific Antibody (CrossMab) Human CrossMab CEA nido-Carboranes Inquiry
CROSSAB-140 Recombinant Anti-CEA x Anti-HSG Bispecific Antibody (CrossMab) Human CrossMab CEA HSG Inquiry
CROSSAB-139 Recombinant Anti-CEA x Anti-GZ (β-galactosidase) Bispecific Antibody (CrossMab) Human CrossMab CEA GZ (β-galactosidase) Inquiry
CROSSAB-138 Recombinant Anti-CEA x Anti-GD2 Bispecific Antibody (CrossMab) Human CrossMab CEA GD2 Inquiry
CROSSAB-137 Recombinant Anti-CEA x Anti-DTPA Bispecific Antibody (CrossMab) Human CrossMab CEA DTPA Inquiry
CROSSAB-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (CrossMab) Human CrossMab CEA DR5 Inquiry
CROSSAB-072 Recombinant Anti-CD3 x Anti-CEA Bispecific Antibody (CrossMab) Human CrossMab CD3 CEA Inquiry
CROSSAB-010 Recombinant Anti-AP (Alkaline Phosphatase) x Anti-CEA Bispecific Antibody (CrossMab) Human CrossMab AP (Alkaline Phosphatase) CEA Inquiry
CROSSAB-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (CrossMab) Human CrossMab Ad Fiber Knob ITGAV Inquiry
CROSSAB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (CrossMab) Human CrossMab Ad Fiber Knob EPCAM Inquiry
CROSSAB-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (CrossMab) Human CrossMab Ad Fiber Knob CD40 Inquiry
IGFV-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (IgG-scFv) Human IgG-scFv CEA TNFα Inquiry
IGFV-141 Recombinant Anti-CEA x Anti-nido-Carboranes Bispecific Antibody (IgG-scFv) Human IgG-scFv CEA nido-Carboranes Inquiry
IGFV-140 Recombinant Anti-CEA x Anti-HSG Bispecific Antibody (IgG-scFv) Human IgG-scFv CEA HSG Inquiry
IGFV-139 Recombinant Anti-CEA x Anti-GZ (β-galactosidase) Bispecific Antibody (IgG-scFv) Human IgG-scFv CEA GZ (β-galactosidase) Inquiry
IGFV-138 Recombinant Anti-CEA x Anti-GD2 Bispecific Antibody (IgG-scFv) Human IgG-scFv CEA GD2 Inquiry
IGFV-137 Recombinant Anti-CEA x Anti-DTPA Bispecific Antibody (IgG-scFv) Human IgG-scFv CEA DTPA Inquiry
IGFV-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (IgG-scFv) Human IgG-scFv CEA DR5 Inquiry
IGFV-072 Recombinant Anti-CD3 x Anti-CEA Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 CEA Inquiry
IGFV-010 Recombinant Anti-AP (Alkaline Phosphatase) x Anti-CEA Bispecific Antibody (IgG-scFv) Human IgG-scFv AP (Alkaline Phosphatase) CEA Inquiry
IGFV-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (IgG-scFv) Human IgG-scFv Ad Fiber Knob ITGAV Inquiry
IGFV-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (IgG-scFv) Human IgG-scFv Ad Fiber Knob EPCAM Inquiry
IGFV-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (IgG-scFv) Human IgG-scFv Ad Fiber Knob CD40 Inquiry
BSDB-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Diabody) Human Diabody CEA TNFα Inquiry
BSDB-141 Recombinant Anti-CEA x Anti-nido-Carboranes Bispecific Antibody (Diabody) Human Diabody CEA nido-Carboranes Inquiry
BSDB-140 Recombinant Anti-CEA x Anti-HSG Bispecific Antibody (Diabody) Human Diabody CEA HSG Inquiry
BSDB-139 Recombinant Anti-CEA x Anti-GZ (β-galactosidase) Bispecific Antibody (Diabody) Human Diabody CEA GZ (β-galactosidase) Inquiry
BSDB-138 Recombinant Anti-CEA x Anti-GD2 Bispecific Antibody (Diabody) Human Diabody CEA GD2 Inquiry
BSDB-137 Recombinant Anti-CEA x Anti-DTPA Bispecific Antibody (Diabody) Human Diabody CEA DTPA Inquiry
BSDB-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Diabody) Human Diabody CEA DR5 Inquiry
BSDB-072 Recombinant Anti-CD3 x Anti-CEA Bispecific Antibody (Diabody) Human Diabody CD3 CEA Inquiry
BSDB-010 Recombinant Anti-AP (Alkaline Phosphatase) x Anti-CEA Bispecific Antibody (Diabody) Human Diabody AP (Alkaline Phosphatase) CEA Inquiry
BSDB-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Diabody) Human Diabody Ad Fiber Knob ITGAV Inquiry
BSDB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Diabody) Human Diabody Ad Fiber Knob EPCAM Inquiry
BSDB-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Diabody) Human Diabody Ad Fiber Knob CD40 Inquiry
BSFAB-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Tandem Fab) Human Tandem Fab CEA TNFα Inquiry
BSFAB-141 Recombinant Anti-CEA x Anti-nido-Carboranes Bispecific Antibody (Tandem Fab) Human Tandem Fab CEA nido-Carboranes Inquiry
BSFAB-140 Recombinant Anti-CEA x Anti-HSG Bispecific Antibody (Tandem Fab) Human Tandem Fab CEA HSG Inquiry
BSFAB-139 Recombinant Anti-CEA x Anti-GZ (β-galactosidase) Bispecific Antibody (Tandem Fab) Human Tandem Fab CEA GZ (β-galactosidase) Inquiry
BSFAB-138 Recombinant Anti-CEA x Anti-GD2 Bispecific Antibody (Tandem Fab) Human Tandem Fab CEA GD2 Inquiry
BSFAB-137 Recombinant Anti-CEA x Anti-DTPA Bispecific Antibody (Tandem Fab) Human Tandem Fab CEA DTPA Inquiry
BSFAB-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Tandem Fab) Human Tandem Fab CEA DR5 Inquiry
BSFAB-072 Recombinant Anti-CD3 x Anti-CEA Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 CEA Inquiry
BSFAB-010 Recombinant Anti-AP (Alkaline Phosphatase) x Anti-CEA Bispecific Antibody (Tandem Fab) Human Tandem Fab AP (Alkaline Phosphatase) CEA Inquiry
BSFAB-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Tandem Fab) Human Tandem Fab Ad Fiber Knob ITGAV Inquiry
BSFAB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Tandem Fab) Human Tandem Fab Ad Fiber Knob EPCAM Inquiry
BSFAB-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Tandem Fab) Human Tandem Fab Ad Fiber Knob CD40 Inquiry
BSFV-142 Recombinant Anti-CEA x Anti-TNFα Bispecific Antibody (Tandem scFv) Human Tandem scFv CEA TNFα Inquiry
BSFV-141 Recombinant Anti-CEA x Anti-nido-Carboranes Bispecific Antibody (Tandem scFv) Human Tandem scFv CEA nido-Carboranes Inquiry
BSFV-140 Recombinant Anti-CEA x Anti-HSG Bispecific Antibody (Tandem scFv) Human Tandem scFv CEA HSG Inquiry
BSFV-139 Recombinant Anti-CEA x Anti-GZ (β-galactosidase) Bispecific Antibody (Tandem scFv) Human Tandem scFv CEA GZ (β-galactosidase) Inquiry
BSFV-138 Recombinant Anti-CEA x Anti-GD2 Bispecific Antibody (Tandem scFv) Human Tandem scFv CEA GD2 Inquiry
BSFV-137 Recombinant Anti-CEA x Anti-DTPA Bispecific Antibody (Tandem scFv) Human Tandem scFv CEA DTPA Inquiry
BSFV-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Tandem scFv) Human Tandem scFv CEA DR5 Inquiry
BSFV-072 Recombinant Anti-CD3 x Anti-CEA Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 CEA Inquiry
BSFV-010 Recombinant Anti-AP (Alkaline Phosphatase) x Anti-CEA Bispecific Antibody (Tandem scFv) Human Tandem scFv AP (Alkaline Phosphatase) CEA Inquiry
BSFV-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Tandem scFv) Human Tandem scFv Ad Fiber Knob ITGAV Inquiry
BSFV-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Tandem scFv) Human Tandem scFv Ad Fiber Knob EPCAM Inquiry
BSFV-002 Recombinant Human Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Tandem scFv) Human Tandem scFv Ad Fiber Knob CD40 Inquiry

Background

Ad fiber knob is a protein present on the surface of adenovirus, a virus commonly used in gene therapy, which is used for the attachment of the virus to a specific receptor on the cell surface. CEA (carcinoembryonic antigen) is a glycoprotein that is overexpressed in various cancer types, such as lung, colorectal, and breast cancers. The anti-Ad fiber knob×anti-CEA bispecific antibody (BsAb) can be constructed to recognize and bind to both the Ad fiber knob and CEA. It aims to deliver adenoviruses specifically to CEA-expressing cancer cells, enhancing virotherapy specificity and efficacy. Additionally, it may stimulate immune responses against cancer cells, potentially boosting antitumor immunity. The potential applications of this BsAb include targeted virotherapy for CEA-expressing cancers, offering improved tumor specificity and therapeutic efficacy in the treatment of solid tumors overexpressing CEA.

Fig.1 Functional mechanisms of Ad fiber knob and CEA. (Krasnykh, et al., 2000; Aquino, et al., 2004) Fig.1 Functions of Ad fiber knob and CEA.1,2

References

  1. Krasnykh, Victor, et al. "Advanced generation adenoviral vectors possess augmented gene transfer efficiency based upon coxsackie adenovirus receptor-independent cellular entry capacity." Cancer Research 60.24 (2000): 6784-6787.
  2. Aquino, Angelo, et al. "Drug-induced increase of carcinoembryonic antigen expression in cancer cells." Pharmacological research 49.5 (2004): 383-396.
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