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CD37 & Saporin Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Target 2 INQUIRY
T-BSDB-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Tandem Diabody) Human CD37 Saporin Inquiry
SCIGG-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (scIgG) Human Single chain IgGs CD37 Saporin Inquiry
FVTIG-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (scFv4-Ig) Human Appended IgGs CD37 Saporin Inquiry
BSSG-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (scFv-IgG) Human Appended IgGs CD37 Saporin Inquiry
IGLFV-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (IgG(L)-scFv) Human Appended IgGs CD37 Saporin Inquiry
BSGV-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (IgG-Fv) Human IgG-Fv CD37 Saporin Inquiry
BSDG-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Fv-IgG) Human Appended IgGs CD37 Saporin Inquiry
BABFV-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins CD37 Saporin Inquiry
FABVC-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins CD37 Saporin Inquiry
SCDBC-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments CD37 Saporin Inquiry
BSDBC-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments CD37 Saporin Inquiry
SCDBF-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments CD37 Saporin Inquiry
BSFVF-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments CD37 Saporin Inquiry
BSDBF-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments CD37 Saporin Inquiry
BSTF-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD37 Saporin Inquiry
BSCFV-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (scFv-Fc) Human scFv-Fc CD37 Saporin Inquiry
MNAB-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Miniantibody) Human Miniantibody CD37 Saporin Inquiry
BSFC-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD37 Saporin Inquiry
BSCC-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD37 Saporin Inquiry
BIBD-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Bibody) Human Bibody CD37 Saporin Inquiry
FABFV-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Fab-Fv) Human Fab-Fv CD37 Saporin Inquiry
MiniB-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Minibody) Human Minibody CD37 Saporin Inquiry
SCDB-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD37 Saporin Inquiry
FABIG-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Fab-IgG) Human Fab-IgG CD37 Saporin Inquiry
TRIB-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Triple Body) Human Triple Body CD37 Saporin Inquiry
BSIG-118 Anti-CD37 x Anti-Saporin Bispecific Antibody (IgG-IgG) Human IgG-IgG CD37 Saporin Inquiry
CROSSAB-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (CrossMab) Human CrossMab CD37 Saporin Inquiry
IGFV-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (IgG-scFv) Human IgG-scFv CD37 Saporin Inquiry
BSDB-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Diabody) Human Diabody CD37 Saporin Inquiry
BSFAB-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Tandem Fab) Human Tandem Fab CD37 Saporin Inquiry
BSFV-118 Recombinant Anti-CD37 x Anti-Saporin Bispecific Antibody (Tandem scFv) Human Tandem scFv CD37 Saporin Inquiry
BSTF-117 Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments CD37 CD64 Inquiry
BSTF-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD22 Saporin Inquiry
BSCFV-H293 Recombinant Human Anti-CD37 x Human Anti-CD64 Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments CD37 CD64 Inquiry
BSCFV-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (scFv-Fc) Human scFv-Fc CD7 Saporin Inquiry
BSCFV-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (scFv-Fc) Human scFv-Fc CD38 Saporin Inquiry
BSCFV-117 Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments CD37 CD64 Inquiry
BSCFV-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (scFv-Fc) Human scFv-Fc CD22 Saporin Inquiry
MNAB-H293 Recombinant Human Anti-CD37 x Human Anti-CD64 Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments CD37 CD64 Inquiry
MNAB-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (Miniantibody) Human Miniantibody CD7 Saporin Inquiry
MNAB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Miniantibody) Human Miniantibody CD38 Saporin Inquiry
MNAB-117 Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments CD37 CD64 Inquiry
MNAB-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Miniantibody) Human Miniantibody CD22 Saporin Inquiry
BSFC-H293 Recombinant Human Anti-CD37 x Human Anti-CD64 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments CD37 CD64 Inquiry
BSFC-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD7 Saporin Inquiry
BSFC-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD38 Saporin Inquiry
BSFC-117 Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments CD37 CD64 Inquiry
BSFC-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD22 Saporin Inquiry
BSCC-H293 Recombinant Human Anti-CD37 x Human Anti-CD64 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments CD37 CD64 Inquiry
BSCC-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD7 Saporin Inquiry
BSCC-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD38 Saporin Inquiry
BSCC-117 Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments CD37 CD64 Inquiry
BSCC-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD22 Saporin Inquiry
BIBD-H293 Recombinant Human Anti-CD37 x Human Anti-CD64 Bispecific Antibody (Bibody) Human Bibody CD37 CD64 Inquiry
BIBD-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (Bibody) Human Bibody CD7 Saporin Inquiry
BIBD-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Bibody) Human Bibody CD38 Saporin Inquiry
BIBD-117 Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (Bibody) Human Bibody CD37 CD64 Inquiry
BIBD-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Bibody) Human Bibody CD22 Saporin Inquiry
FABFV-H293 Recombinant Human Anti-CD37 x Human Anti-CD64 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD37 CD64 Inquiry
FABFV-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (Fab-Fv) Human Fab-Fv CD7 Saporin Inquiry
FABFV-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Fab-Fv) Human Fab-Fv CD38 Saporin Inquiry
FABFV-117 Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD37 CD64 Inquiry
FABFV-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Fab-Fv) Human Fab-Fv CD22 Saporin Inquiry
MiniB-H293 Recombinant Human Anti-CD37 x Human Anti-CD64 Bispecific Antibody (Minibody) Human Minibody CD37 CD64 Inquiry
MiniB-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (Minibody) Human Minibody CD7 Saporin Inquiry
MiniB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Minibody) Human Minibody CD38 Saporin Inquiry
MiniB-117 Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (Minibody) Human Minibody CD37 CD64 Inquiry
MiniB-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Minibody) Human Minibody CD22 Saporin Inquiry
SCTB-H183 Recombinant Human Anti-CD37 x Anti-CD64 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD37 CD64 Inquiry
SCDB-H291 Recombinant Human Anti-CD37 x Anti-CD64 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD37 CD64 Inquiry
FABIG-H291 Recombinant Human Anti-CD37 x Anti-CD64 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD37 CD64 Inquiry
TRIB-H293 Recombinant Human Anti-CD37 x Anti-CD64 Bispecific Antibody (Triple Body) Human Triple Body CD37 CD64 Inquiry
BSIG-H291 Human Anti-CD37 x Anti-CD64 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD37 CD64 Inquiry
CROSSAB-H291 Recombinant Human Anti-CD37 x Anti-CD64 Bispecific Antibody (CrossMab) Human CrossMab CD37 CD64 Inquiry
IGFV-H291 Recombinant Human Anti-CD37 x Anti-CD64 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD37 CD64 Inquiry
BSDB-H291 Recombinant Human Anti-CD37 x Anti-CD64 Bispecific Antibody (Diabody) Human Diabody CD37 CD64 Inquiry
BSFAB-H291 Recombinant Human Anti-CD37 x Anti-CD64 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD37 CD64 Inquiry
BSFV-H291 Recombinant Human Anti-CD37 x Anti-CD64 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD37 CD64 Inquiry
SCTB-088 Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD37 CD64 Inquiry
SCDB-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD7 Saporin Inquiry
SCDB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD38 Saporin Inquiry
SCDB-117 Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD37 CD64 Inquiry
SCDB-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD22 Saporin Inquiry
FABIG-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (Fab-IgG) Human Fab-IgG CD7 Saporin Inquiry
FABIG-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Fab-IgG) Human Fab-IgG CD38 Saporin Inquiry
FABIG-117 Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD37 CD64 Inquiry
FABIG-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Fab-IgG) Human Fab-IgG CD22 Saporin Inquiry
TRIB-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (Triple Body) Human Triple Body CD7 Saporin Inquiry
TRIB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Triple Body) Human Triple Body CD38 Saporin Inquiry
TRIB-117 Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (Triple Body) Human Triple Body CD37 CD64 Inquiry
TRIB-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Triple Body) Human Triple Body CD22 Saporin Inquiry
BSIG-130 Anti-CD7 x Anti-Saporin Bispecific Antibody (IgG-IgG) Human IgG-IgG CD7 Saporin Inquiry
BSIG-120 Anti-CD38 x Anti-Saporin Bispecific Antibody (IgG-IgG) Human IgG-IgG CD38 Saporin Inquiry
BSIG-117 Anti-CD37 x Anti-CD64 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD37 CD64 Inquiry
BSIG-053 Anti-CD22 x Anti-Saporin Bispecific Antibody (IgG-IgG) Human IgG-IgG CD22 Saporin Inquiry
CROSSAB-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (CrossMab) Human CrossMab CD7 Saporin Inquiry
CROSSAB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (CrossMab) Human CrossMab CD38 Saporin Inquiry
CROSSAB-117 Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (CrossMab) Human CrossMab CD37 CD64 Inquiry
CROSSAB-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (CrossMab) Human CrossMab CD22 Saporin Inquiry
IGFV-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (IgG-scFv) Human IgG-scFv CD7 Saporin Inquiry
IGFV-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (IgG-scFv) Human IgG-scFv CD38 Saporin Inquiry
IGFV-117 Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD37 CD64 Inquiry
IGFV-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (IgG-scFv) Human IgG-scFv CD22 Saporin Inquiry
BSDB-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (Diabody) Human Diabody CD7 Saporin Inquiry
BSDB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Diabody) Human Diabody CD38 Saporin Inquiry
BSDB-117 Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (Diabody) Human Diabody CD37 CD64 Inquiry
BSDB-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Diabody) Human Diabody CD22 Saporin Inquiry
BSFAB-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (Tandem Fab) Human Tandem Fab CD7 Saporin Inquiry
BSFAB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Tandem Fab) Human Tandem Fab CD38 Saporin Inquiry
BSFAB-117 Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD37 CD64 Inquiry
BSFAB-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Tandem Fab) Human Tandem Fab CD22 Saporin Inquiry
BSFV-130 Recombinant Anti-CD7 x Anti-Saporin Bispecific Antibody (Tandem scFv) Human Tandem scFv CD7 Saporin Inquiry
BSFV-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Tandem scFv) Human Tandem scFv CD38 Saporin Inquiry
BSFV-117 Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD37 CD64 Inquiry
BSFV-053 Recombinant Anti-CD22 x Anti-Saporin Bispecific Antibody (Tandem scFv) Human Tandem scFv CD22 Saporin Inquiry

Background

CD37, a tetraspanin expressed on B cells and some T cells, plays a fundamental role in B cell function and humoral immunity, and is also implicated in the pathogenesis of various B cell malignancies. Saporin, a ribosome-inactivating protein derived from the seeds of the plant Saponaria officinalis, works by inhibiting protein synthesis, leading to cell death. The anti-CD37×anti-saporin bispecific antibody (BsAb) can be constructed by combining one antibody targeting CD37 and the other targeting saporin. This BsAb can selectively bind to CD37-expressing B cells and deliver saporin to induce targeted cell death. The mechanism supposedly involves the BsAb binding to CD37-expressing B cells, internalizing the antibody-saporin complex, and inducing cell death through inhibition of protein synthesis. This BsAb can be used in the research of B cell malignancies, such as chronic lymphocytic leukemia and non-Hodgkin lymphoma.

Fig.1 Functional mechanisms of CD37 and saporin. (Bertoni and Anastasios, 2016; Polito, et al., 2013) Fig.1 The biological roles of CD37 and saporin.1,2

Reference

  1. Bertoni, Francesco, and Anastasios Stathis. "Staining the target: CD37 expression in lymphomas." Blood, The Journal of the American Society of Hematology 128.26 (2016): 3022-3023.
  2. Polito, Letizia, et al. "Saporin-S6: a useful tool in cancer therapy." Toxins 5.10 (2013): 1698-1722.
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