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DR5 & FAP Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Target 2 INQUIRY
T-BSDB-H318 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (Tandem Diabody) Human DR5 FAP Inquiry
T-BSDB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Tandem Diabody) Human DR5 FAP Inquiry
SCIGG-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scIgG) Human Single chain IgGs DR5 FAP Inquiry
SCIGG-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scIgG) Human Single chain IgGs DR5 FAP Inquiry
FVTIG-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scFv4-Ig) Human Appended IgGs DR5 FAP Inquiry
FVTIG-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scFv4-Ig) Human Appended IgGs DR5 FAP Inquiry
BSSG-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scFv-IgG) Human Appended IgGs DR5 FAP Inquiry
BSSG-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scFv-IgG) Human Appended IgGs DR5 FAP Inquiry
IGLFV-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (IgG(L)-scFv) Human Appended IgGs DR5 FAP Inquiry
IGLFV-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (IgG(L)-scFv) Human Appended IgGs DR5 FAP Inquiry
BSGV-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (IgG-Fv) Human IgG-Fv DR5 FAP Inquiry
BSGV-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (IgG-Fv) Human IgG-Fv DR5 FAP Inquiry
BSDG-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Fv-IgG) Human Appended IgGs DR5 FAP Inquiry
BSDG-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Fv-IgG) Human Appended IgGs DR5 FAP Inquiry
BABFV-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins DR5 FAP Inquiry
BABFV-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins DR5 FAP Inquiry
FABVC-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins DR5 FAP Inquiry
FABVC-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins DR5 FAP Inquiry
SCDBC-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments DR5 FAP Inquiry
SCDBC-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments DR5 FAP Inquiry
BSDBC-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments DR5 FAP Inquiry
BSDBC-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments DR5 FAP Inquiry
SCDBF-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments DR5 FAP Inquiry
SCDBF-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments DR5 FAP Inquiry
BSFVF-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments DR5 FAP Inquiry
BSFVF-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments DR5 FAP Inquiry
BSDBF-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments DR5 FAP Inquiry
BSDBF-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments DR5 FAP Inquiry
BSTF-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments DR5 FAP Inquiry
BSTF-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments DR5 FAP Inquiry
BSCFV-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments DR5 FAP Inquiry
BSCFV-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments DR5 FAP Inquiry
MNAB-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments DR5 FAP Inquiry
MNAB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments DR5 FAP Inquiry
BSFC-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments DR5 FAP Inquiry
BSFC-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments DR5 FAP Inquiry
BSCC-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments DR5 FAP Inquiry
BSCC-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments DR5 FAP Inquiry
BIBD-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Bibody) Human Bibody DR5 FAP Inquiry
BIBD-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Bibody) Human Bibody DR5 FAP Inquiry
FABFV-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Fab-Fv) Human Fab-Fv DR5 FAP Inquiry
FABFV-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Fab-Fv) Human Fab-Fv DR5 FAP Inquiry
MiniB-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Minibody) Human Minibody DR5 FAP Inquiry
MiniB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Minibody) Human Minibody DR5 FAP Inquiry
SCDB-H318 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody DR5 FAP Inquiry
FABIG-H318 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (Fab-IgG) Human Fab-IgG DR5 FAP Inquiry
TRIB-H320 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (Triple Body) Human Triple Body DR5 FAP Inquiry
BSIG-H318 Human Anti-DR5 x Anti-FAP Bispecific Antibody (IgG-IgG) Human IgG-IgG DR5 FAP Inquiry
CROSSAB-H318 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (CrossMab) Human CrossMab DR5 FAP Inquiry
IGFV-H318 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (IgG-scFv) Human IgG-scFv DR5 FAP Inquiry
BSDB-H318 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (Diabody) Human Diabody DR5 FAP Inquiry
BSFAB-H318 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (Tandem Fab) Human Tandem Fab DR5 FAP Inquiry
BSFV-H317 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (Tandem scFv) Human Tandem scFv DR5 FAP Inquiry
SCDB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody DR5 FAP Inquiry
FABIG-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Fab-IgG) Human Fab-IgG DR5 FAP Inquiry
TRIB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Triple Body) Human Triple Body DR5 FAP Inquiry
BSIG-152 Anti-DR5 x Anti-FAP Bispecific Antibody (IgG-IgG) Human IgG-IgG DR5 FAP Inquiry
CROSSAB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (CrossMab) Human CrossMab DR5 FAP Inquiry
IGFV-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (IgG-scFv) Human IgG-scFv DR5 FAP Inquiry
BSDB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Diabody) Human Diabody DR5 FAP Inquiry
BSFAB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Tandem Fab) Human Tandem Fab DR5 FAP Inquiry
BSFV-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Tandem scFv) Human Tandem scFv DR5 FAP Inquiry
BSTF-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments CEA DR5 Inquiry
BSTF-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments CD3 FAP Inquiry
BSCFV-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments CEA DR5 Inquiry
BSCFV-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments CD3 FAP Inquiry
BSCFV-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments CEA DR5 Inquiry
BSCFV-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments CD3 FAP Inquiry
MNAB-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments CEA DR5 Inquiry
MNAB-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments CD3 FAP Inquiry
MNAB-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments CEA DR5 Inquiry
MNAB-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments CD3 FAP Inquiry
BSFC-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments CEA DR5 Inquiry
BSFC-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments CD3 FAP Inquiry
BSFC-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments CEA DR5 Inquiry
BSFC-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments CD3 FAP Inquiry
BSCC-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments CEA DR5 Inquiry
BSCC-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments CD3 FAP Inquiry
BSCC-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments CEA DR5 Inquiry
BSCC-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments CD3 FAP Inquiry
BIBD-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (Bibody) Human Bibody CEA DR5 Inquiry
BIBD-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (Bibody) Human Bibody CD3 FAP Inquiry
BIBD-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Bibody) Human Bibody CEA DR5 Inquiry
BIBD-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Bibody) Human Bibody CD3 FAP Inquiry
FABFV-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (Fab-Fv) Human Fab-Fv CEA DR5 Inquiry
FABFV-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 FAP Inquiry
FABFV-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Fab-Fv) Human Fab-Fv CEA DR5 Inquiry
FABFV-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 FAP Inquiry
MiniB-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (Minibody) Human Minibody CEA DR5 Inquiry
MiniB-H256 Recombinant Human Anti-CD3 x Human Anti-FAP Bispecific Antibody (Minibody) Human Minibody CD3 FAP Inquiry
MiniB-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Minibody) Human Minibody CEA DR5 Inquiry
MiniB-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Minibody) Human Minibody CD3 FAP Inquiry
SCTB-H151 Recombinant Human Anti-FAP x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 FAP Inquiry
SCDB-H306 Recombinant Human Anti-CEA x Anti-DR5 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CEA DR5 Inquiry
SCDB-H254 Recombinant Human Anti-CD3 x Anti-FAP Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 FAP Inquiry
FABIG-H306 Recombinant Human Anti-CEA x Anti-DR5 Bispecific Antibody (Fab-IgG) Human Fab-IgG CEA DR5 Inquiry
FABIG-H254 Recombinant Human Anti-CD3 x Anti-FAP Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 FAP Inquiry
TRIB-H308 Recombinant Human Anti-CEA x Anti-DR5 Bispecific Antibody (Triple Body) Human Triple Body CEA DR5 Inquiry
TRIB-H256 Recombinant Human Anti-CD3 x Anti-FAP Bispecific Antibody (Triple Body) Human Triple Body CD3 FAP Inquiry
BSIG-H306 Human Anti-CEA x Anti-DR5 Bispecific Antibody (IgG-IgG) Human IgG-IgG CEA DR5 Inquiry
BSIG-H254 Human Anti-CD3 x Anti-FAP Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 FAP Inquiry
CROSSAB-H306 Recombinant Human Anti-CEA x Anti-DR5 Bispecific Antibody (CrossMab) Human CrossMab CEA DR5 Inquiry
CROSSAB-H254 Recombinant Human Anti-CD3 x Anti-FAP Bispecific Antibody (CrossMab) Human CrossMab CD3 FAP Inquiry
IGFV-H306 Recombinant Human Anti-CEA x Anti-DR5 Bispecific Antibody (IgG-scFv) Human IgG-scFv CEA DR5 Inquiry
IGFV-H254 Recombinant Human Anti-CD3 x Anti-FAP Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 FAP Inquiry
BSDB-H306 Recombinant Human Anti-CEA x Anti-DR5 Bispecific Antibody (Diabody) Human Diabody CEA DR5 Inquiry
BSDB-H254 Recombinant Human Anti-CD3 x Anti-FAP Bispecific Antibody (Diabody) Human Diabody CD3 FAP Inquiry
BSFAB-H306 Recombinant Human Anti-CEA x Anti-DR5 Bispecific Antibody (Tandem Fab) Human Tandem Fab CEA DR5 Inquiry
BSFAB-H254 Recombinant Human Anti-CD3 x Anti-FAP Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 FAP Inquiry
BSFV-H306 Recombinant Human Anti-CEA x Anti-DR5 Bispecific Antibody (Tandem scFv) Human Tandem scFv CEA DR5 Inquiry
BSFV-H254 Recombinant Human Anti-CD3 x Anti-FAP Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 FAP Inquiry
SCTB-053 Recombinant Anti-FAP x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 FAP Inquiry
SCDB-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CEA DR5 Inquiry
SCDB-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 FAP Inquiry
FABIG-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Fab-IgG) Human Fab-IgG CEA DR5 Inquiry
FABIG-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 FAP Inquiry
TRIB-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Triple Body) Human Triple Body CEA DR5 Inquiry
TRIB-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Triple Body) Human Triple Body CD3 FAP Inquiry
BSIG-136 Anti-CEA x Anti-DR5 Bispecific Antibody (IgG-IgG) Human IgG-IgG CEA DR5 Inquiry
BSIG-080 Anti-CD3 x Anti-FAP Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 FAP Inquiry
CROSSAB-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (CrossMab) Human CrossMab CEA DR5 Inquiry
CROSSAB-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (CrossMab) Human CrossMab CD3 FAP Inquiry
IGFV-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (IgG-scFv) Human IgG-scFv CEA DR5 Inquiry
IGFV-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 FAP Inquiry
BSDB-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Diabody) Human Diabody CEA DR5 Inquiry
BSDB-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Diabody) Human Diabody CD3 FAP Inquiry
BSFAB-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Tandem Fab) Human Tandem Fab CEA DR5 Inquiry
BSFAB-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 FAP Inquiry
BSFV-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Tandem scFv) Human Tandem scFv CEA DR5 Inquiry
BSFV-080 Recombinant Anti-CD3 x Anti-FAP Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 FAP Inquiry

Background

Death receptor 5 (DR5) and fibroblast-activation protein (FAP) are both instrumental regulators involved with different processes of tumors. DR5, a member of the TNF-receptor superfamily, is initially recognized as a cell receptor of TRAIL. DR5 participates in apoptosis via the formation of death-inducing signaling complexes, thus triggering multiple downstream signaling pathways. As inducing apoptosis in cancer cells has long been a popular drug R&D strategy for various cancers, DR5 attracts much attention as a promising target. FAP is a homodimeric membrane protein possessing high expression levels in reactive stromal fibroblasts of most epithelial malignancies. It plays important roles in the development, growth, and metastasis of tumors and is also regarded as an ideal target for cancer therapeutics.

DR5&FAP bispecific antibodies (BsAbs) can synchronously target DR5 on tumor cells and FAP on cancer-associated fibroblasts in tumor stroma, exhibiting the ability to activate potent tumor cell apoptosis in vitro and in vivo in preclinical tumor models.

Signaling pathways of DR5 (a) and FAP (b). (Dubuisson, et al, 2017; Fitzgerald, et al, 2020) Fig.1 DR5 pathway (a) and FAP pathway (b).1, 2

References

  1. Dubuisson, Agathe, and Olivier Micheau. "Antibodies and derivatives targeting DR4 and DR5 for cancer therapy." Antibodies 6.4 (2017): 16.
  2. Fitzgerald, Allison A., and Louis M. Weiner. "The role of fibroblast activation protein in health and malignancy." Cancer and Metastasis Reviews 39.3 (2020): 783-803.
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