With the rapid development of new biotechnologies, numerous antibodies (e.g., monoclonal, polyclonal, recombinant antibodies) are being developed and used for the diagnosis of diseases and infections. At Creative Biolabs, you can find the most comprehensive first-rate in vitro diagnostic (IVD) antibody development services for diversified diagnostic applications. Particularly, we provide custom development, manufacture, and commercial licensing of high-quality antibodies for the diagnosis of Chagas.
Introduction of Chagas Disease
Chagas disease is an anthropozoonosis caused by the hemoflagellate protozoan Trypanosoma cruzi, which was identified more than 100 years ago. Chagas disease has two successive phases: an acute phase and a chronic phase. Most acute phases are asymptomatic or have non-specific symptoms. The acute phase usually resolves spontaneously after which time patients remain chronically infected if untreated. Most people never develop symptoms but some may progress to clinical forms of the disease (cardiac, digestive and/or neurological), which can be life-threatening if left undiagnosed and untreated.
Fig.1 Life cycle of T. cruzi.
Laboratory Diagnosis of Chagas
The laboratory diagnosis of the Chagas disease mainly includes parasitological methods (e.g., microscopy, PCR) and serological testing. During the acute phase, diagnosis is made by detection of the parasite in the blood (parasitological methods), while during the chronic phase, diagnosis is made via the detection of antibodies against T. cruzi (serological techniques).
Fig.2 Photomicrograph of Giemsa-stained T. cruzi.2
Antibody-based diagnostic tools are widely used to help clinicians to diagnose and assess the progression of different diseases. As an IVD antibody specialist, Creative Biolabs offers a full range of IVD antibody development services for different applications, such as lateral flow and ELISA. With abundant experience and advanced technology, we can provide antibodies that have the sensitivity and consistency to provide optimal performance in the immunoassays. Contact us to discuss your requirements and experience the great value of our expert services.
References
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