As a leading antibody service provider in the world, Creative Biolabs has worked in the field of in vitro diagnostic (IVD) for many years. With extensive experience and advanced technology, we provide IVD antibody development services against syphilis for our worldwide customers.

Introduction of Syphilis

Syphilis is a systemic sexually transmitted infection caused by the spirochetal pathogen Treponema pallidum. T. pallidum is a motile spirochete and the causative microorganism of syphilis that belongs to one of five genera within the order Spirochaetales. It has been reported that four human diseases can be induced by members of the genus Treponema, including venereal syphilis, endemic syphilis, yaws, and pinta. As a sexually transmitted disease for at least five centuries, the infection of syphilis can facilitate the transmission of HIV infection, increase the risk of adverse pregnancy outcomes, and cause a substantial economic impact. Importantly, over 12 million people are infected with syphilis in the world every year, especially in majority developing countries.

Fig.1 The T. pallidum morphology, highlighted in gold. (https://commons.wikimedia.org/wiki/File:Treponema_pallidum_Bacteria_(Syphilis).jpg)Fig.1 Electron micrograph image of T. pallidum, highlighted in gold.1

Correlation of Syphilis and STDs

Syphilis is a multistage disease that is usually transmitted through various routes, including direct sexual contact with infectious lesions, transplacental spread from infected mother to fetus, or via blood transfusion. And the most common mode of transmission is sexual. Generally, transmission occurs when the host's highly infectious skin lesions make direct contact with the partner, and the spirochete is able to enter the body through mucous membranes. Transmission via oral sex is possible if the infected individual has active lesions on the oral mucosa. In addition, T pallidum has the ability to cross the placenta and infect a fetus at any gestational age or clinical stage of syphilis. Given the universal screening of blood donors, transmission through transfusion is decreased in recent years.

Fig.2 Syphilis infection during pregnancy. (Sankaran, Elizabeth and Satyan, 2023)Fig.2 Clinical features of perinatal syphilis and risk of maternal-to-fetal transmission.2

IVD Antibody Development Services for Syphilis

In the past years, the rapid development of IVD technology has greatly accelerated the diagnostic industry. In the IVD industry, antibody-based immunodiagnostic kits have been the most commonly used tools for disease screening, diagnosis, prognosis, and therapeutic monitoring. With years of experience and advanced technology platforms, Creative Biolabs has developed a series of high-quality IVD antibody development services for our clients all over the world to promote their IVD projects a success. Besides antibody generation, Creative Biolabs also offers diagnostic immunoassay development services, including feasibility analysis, assay design, assay protocol establishment, assay optimization, and kit production.

Our high-affinity IVD antibodies will contribute greatly to the success of your projects. For more details and information, please feel free to contact us or directly send us an inquiry. We will get in touch with you as soon as possible.

References

  1. From Wikimedia: By NIAID, CC BY 2.0, without modification, https://commons.wikimedia.org/wiki/File:Treponema_pallidum_Bacteria_(Syphilis).jpg.
  2. Sankaran, Deepika, Elizabeth Partridge, and Satyan Lakshminrusimha. "Congenital syphilis—an illustrative review." Children 10.8 (2023): 1310. Distributed under Open Access license CC BY 4.0, without modification.

For Research Use Only.



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