Patented Transgenic CAMouse™
Transgenic mice producing human antibodies has been a new trend in therapeutic antibody development over years. By introducing human immunoglobulin loci (heavy and light chains) into the mouse germlines with inactivated/disrupted endogenous antibody machinery, the transgenic mouse/rat strains can directly generate high affinity, fully human antibodies, which avoid the subsequent costly and tedious in vitro humanization and affinity maturation process.
Featured Antibody Discovery Strategies
Equipped with cutting-edge techniques and vast experience, Creative Biolabs has established an all-round platform for antibody discovery and engineering. Our scientists are your trustworthy companion, dedicated to helping you with every single step via multiple innovative strategies.
Superior Transgenic Technique Platform
With the exclusive and powerful transgenic technique that can introduce large gene fragments (as long as 800 kb) precisely in one time, the CAMouse™ strains guarantee fully-human antibody generation (including constant regions) as well as extremely diversified antibody repertoire.
Excellent Immune System Performance
For most antibody discovery projects, potent immune response is the most important prerequisite for downstream development. One great advantage of CAMouse™ is that it can achieve 100% human sequences without compromising antibody generation route (e.g. B cell maturation). Therefore, large pools of fully human antibodies against indicated targets can be guaranteed.
