Creative Biolabs brings together the market-leading antibody discovery expertise to launch the CAMouse™ VHH strain, which has the ability to produce human heavy chain only antibodies for therapeutic/diagnostic applications.

Introduction of CAMouse™ VHH Strain

Single domain antibodies (sdAbs) are a special antibody type with single monomeric heavy chains which were first found in camelids. Except for the common features of other mAbs, sdAbs provide many unique properties such as higher affinity, favorable biophysical stability, recognition of conformational epitopes, simplicity to manufacture, etc. However, immunogenicity risks are a general concern due to the camelid origin. To overcome these limitations, the CAMouse™ VHH strain has been successfully developed, which is capable of raising large repertoires of human heavy-chain-only antibodies, a mimic version of humanized sdAbs.

The unique and patented CAMouse™ VHH strain is based on the world-leading transgene technique with incomparable length and efficiency. Human immunoglobulin heavy chain locus (without CH1 domain) were selectively introduced into endogenous mouse Ig-inactivated mice. After challenged with immunogens, the mice can synthesize a diverse pool of antibodies consisting of only heavy chains.

Attractive Features of the CAMouse™ VHH Strain Antibody Discovery Service

• Fully human origin: The genetically-engineered mice serve as a powerful toolbox for generation of affinity-matured, humanized variable regions with intrinsic drug-like properties, which are very necessary for successful development including high potency, specificity, manufacturability, solubility and low risk of immunogenicity.
• Innovative heavy-chain-only format: Being similar to sdAbs, the extra small size of human heavy-chain-only antibodies allows for increased flexibility, better penetration (e.g. cross the blood-brain barrier), higher accessibility to conformational epitopes, and easier for production.
• Versatile technology platforms: Various approaches including hybridomas, phage display, B cell sorting can be incorporated with CAMouse™ VHH strain for downstream antibody discovery.
• Time- and labor-saving: CAMouse™ VHH strain can greatly facilitate your drug discovery or pre-clinical timeline by skipping the time-consuming antibody humanization and affinity maturation process in vitro.
• Skillful, all-round custom service & tech support: With more than 10 years’ experience in antibody development, our scientific team provides first-class, custom-oriented service throughout the project. We tailor customized proposals on case-to-case basis and will work closely with clients step-by-step to ensure the most satisfactory outcome.

Creative Biolabs is dedicated to helping our clients deliver diverse research goals with our professional service & support. Please do not hesitate to contact us for more details.

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Please note: we only produce antibodies for research purposes. Our products and services cannot be used directly on humans.