Short Description
Simplify HDAC5 staining with this comprehensive IHC kit, featuring pre-optimized reagents for a straightforward antigen retrieval to mounting procedure.
Description
Histone acetylation and deacetylation play key roles in regulating DNA accessibility to transcription factors. Among the four identified classes of HDACs, HDAC5 is a class II HDAC that deacetylates lysine residues on the N-terminal regions of core histones (H2A, H2B, H3, and H4). This process is vital for transcriptional regulation, cell cycle progression, and developmental events. HDAC5 also plays a role in muscle maturation by repressing the transcription of myocyte enhancer MEF2C. During muscle differentiation, HDAC5 moves to the cytoplasm, enabling myocyte enhancer factor expression.
Features
Ready to use
High Sensitivity Streptavidin (HSS) increases detection sensitivity
Suitable for tissue sections & cytospin preparations
Pre-diluted reagents minimize hands-on time
Optimizes mouse, rabbit, rat, goat, or sheep IgG primary antibody staining
Reactivity
Human, Mouse, Rat
Analytical Method
Immunohistochemistry
Datasheet
