Services - Creative Biolabs

Antibody and Protein Development

The Schematic of Antibodies. (Creative Biolabs Authorized)

Therapeutic Antibody & Protein Development Service

Creative Biolabs is your partner in designing optimum therapeutic antibodies and proteins. With years of experience in biotech, we can provide an extensive array of services for finding, developing, and optimizing therapeutic antibodies and proteins. Our team has the latest tools and technologies to support our clients in every phase of antibody and protein drug discovery, from target discovery to IND regulatory assistance. We have a deep understanding of all therapeutics from monoclonal antibodies to bispecific antibodies, antibody-drug conjugates (ADCs), enzymes, cytokines, and membrane proteins. We bring together the most advanced technology and decades of expertise to deliver complete solutions for the most demanding therapeutic protein research.

Key Services Offered

Monoclonal Antibody Development	Complete monoclonal antibody development services for research use.
Bispecific Antibody Development	Design and production of bispecific antibodies to improve disease immunity.
Antibody-Drug Conjugates (ADCs)	Construction of ADCs to selectively inhibit cancer cells and reduce off-target toxicity.
Engineering of Enzymes and Cytokine	Therapeutic application of enzymes and cytokines.
Membrane Protein Production	Expression and purification of membrane proteins for drug screening and structure analysis.

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Cancer Immunotherapy Solutions

Creative Biolabs is pleased to offer a full-service solution for cancer immunotherapy development. Our process brings the most advanced technologies along with a tailored treatment plan, resulting in targeted, more effective therapies. We offer all aspects of cancer immunotherapy, from preclinical discovery to clinical applications.

In Vitro ADME for Cancer Immunotherapy

Creative Biolabs provides a complete in vitro absorption, distribution, metabolism, and excretion (ADME) service to speed up the development of cancer immunotherapy. Our in vitro ADME assays are key for studying how therapeutics operate in the body and are critical for fine-tuning candidate drugs prior to clinical trial. We provide a wide array of assays, such as:

Plasma Stability Determination	Evaluates the stability of potential drugs in plasma。
CYP Enzyme Inhibition and CYP Induction	Determine if a drug interferes with cytochrome P450 enzymes that play an important role in drug metabolism.
Cell Permeability	Rates the ability of a drug to cross cell membranes and get to the target.
Renal Excretion	Examines the renal excretion of a drug, a key component of its pharmacokinetics.
Metabolite Analysis	Identify and measure metabolites generated by the metabolism of a drug to understand how it is biotransformed.

Comprehensive Solution for Cancer Immunotherapy Research

Creative Biolabs offers cancer immunotherapy development as a multidisciplinary solution. This includes a blend of gene editing, antibody targeting, and immune modulation to enhance cancer treatments. Our experts work directly with our clients to create custom solutions for each research agenda and patient.

Targeting Ferroptosis Solutions in Oncology

Ferroptosis, a form of controlled cell death, has received enormous media attention for its causal influence on the development and progression of chronic illnesses such as cancer. In contrast to apoptosis, ferroptosis causes iron-dependent peroxidation of lipids and death. More recently, ferroptosis has been shown to inhibit tumor growth and make many cancers more susceptible to chemotherapy and immunotherapy. That makes ferroptosis a promising candidate for novel cancer treatments. At Creative Biolabs, we have developed a comprehensive tumor ferroptosis analysis platform to assist in the identification and development of novel ferroptosis therapeutic approaches. Our platform is built to rationally seek and test novel ferroptosis targets, discover how they work, and learn how they might work in combination with other cancer therapies.

Fig.1 Molecular basis of ferroptosis and strategies for therapeutic induction of ferroptosis.¹

Synthetic Gene Circuits for Cancer Immunotherapy

We're the leading experts in the engineering and fabrication of synthetic gene circuits that control cancer cells. These new circuits could turn cancer cells against themselves, and present new avenues for breaking through the resistance of existing treatments. If we implant artificial circuits in cancer cells, we can alter their immune responses and increase their vulnerability to immune targeting therapies. Applications of gene circuits include:

Increase the capacity of the immune system to kill cancer cells.
Stimulating a stronger immune system with gene circuit engineering.
Delivering an alternative treatment to cancers that have failed on standard therapies.

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Cancer Targeting and Tumor Profiling

Tumor Profiling to Guide Targeted Cancer Therapy

Creative Biolabs offers fast, accurate tumor profiling for the direction of targeted cancer therapies. Through our cutting-edge technologies, we provide a deep understanding of the molecular biology of tumors to support more precise diagnosis and personalized treatment. Our tumor profiling services help researchers and clinicians to gain insights into tumor heterogeneity and how cancer progresses.

Tumor Energy Metabolism Analysis Services

We perform the metabolic analysis of tumors that helps us to unravel the processes regulating metabolic metabolism in cancer cells, which can help us understand how tumors keep growing and avoid treatments. Our work in the metabolic metabolism of tumor cells offers new targets for metabolic cancer therapies.

Functional Genetic Screening for Tumor Metabolism	Exploring the functions of metabolic genes and enzymes for cancer and metabolic diseases.
Tumor Cellular Metabolism Analysis	Understanding metabolic pathways and how cancer cells keep themselves alive and in expansion and monitoring of key metabolic metrics, such as ATP and glucose absorption, for tumor metabolism.
In Vivo Tumor Metabolism Analysis	Discovery of targets for metabolic-based cancer therapies.

Human Oncology Imaging Services

Creative Biolabs provides all aspects of oncology imaging that involves medical scans, equipment evaluation, and sophisticated computer simulations. These services allow scientists to look inside tumors at the cellular level, and provide insights for cancer diagnosis, treatment, and assessment.

Medical Imaging	High-definition images to visualize tumor growth and progression.
Tracking the Lineage	Examining the genealogy of cancer cells, to identify how they developed and how they respond to therapy.
Quantitative Imaging	Use of imaging to monitor the progression of tumors and evaluate the long-term efficacy of treatments.

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Microbiome and Immunological Research

Gut Microbiota-based Diagnostics Platform

It's important to note that the gut microbiome is also fundamental to human health – affecting how disease begins, progresses, and responds to therapy. At Creative Biolabs, we offer a suite of microbiome-based diagnostic services to pinpoint microbial biomarkers and their involvement in diseases.

Microbiome Profiling	Monitoring microbial DNA to learn how it leads to disease states.
Metabolomics	Using LC-MS and GC-MS to detectmetabolic alterations in cancer cells.
Biomarker Discovery	Finding microbial biomarkers to predict disease pathologies and guide targeted therapies.

Brain-Immune-Gut-based Integrative Research

These integrative studies look at how the brain, immune system, and gut interact. By understanding these interactions, we can create more effective therapies for cancer and other disorders. We perform cutting-edge research to unravel the brain-gut-immune axis and its role in disease progression.

Brain-Gut Interactions	Understanding how the gut modifies the brain and vice versa.
Gut Microbiota and Neuro Diseases	Understanding how nervous systems are influenced by gut microbiotaalterations.
Personalized Assays	Development of bespoke assays to examine the brain-immune-gut axis in both health and disease.

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Graft-Versus-Host Disease (GVHD) and Other services

Graft-Versus-Host Disease (GVHD) Research Solutions

Creative Biolabs offers innovative technologies for GVHD diagnosis, prediction, and treatment, such as mass spectrometry. Our study aims to optimize outcomes for allogeneic HCT and prevent GVHD.

GVHD Diagnosis Research	Developing various GVHD diagnostic tools with advanced molecular diagnostic techniques.
GVHD Marker Identification	Mass spectrometry detection of biomarkers for GVHD detection early on.
GVHD Therapy Discovery	Driving progress in GVHD therapy by validating targets, screening drugs, and evaluating preclinical models.
Metabolite Profiling	Identifying the contribution of metabolites to GVHD pathogenesis and discovering targets for therapeutic intervention.

Cancer Resistance Intergated Solutions

We provide tailored solutions to treat cancer resistance by detecting resistance markers and implementing targeted therapies. Our research allows us to break through the limiting mechanisms of cancer treatment to deliver a more integrated approach to treating cancer.

The Schematic of Heart. (Creative Biolabs Authorized)

Cardiotoxicity Analysis & Prevention Solutions

At Creative Biolabs, it is essential to comprehend the delicate balance between heart health and the anticancer properties of candidate drugs. By employing state-of-the-art experimental techniques and analytical approaches, we can accurately assess the potential cardiotoxic effects of anticancer drugs. Meanwhile, combining pharmacology, toxicology, and animal model analysis, we can help our customers effectively prevent and eliminate potential cardiotoxicity problems.

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For more information about how Creative Biolabs can assist you in your research and therapeutic creation, contact us today! Our specialists are ready to offer tailored solutions based on your scientific and clinical objectives. From early-stage research to clinical trials, Creative Biolabs can support you. Contact our customer support or visit our website to find out more details or discuss your project. Come to work with us!

We Are Ready to Assist!

Great Partners of Creative Biolabs. (Creative Biolabs Authorized)

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Trust Creative Biolabs to deliver tailored solutions, offering precise and actionable insights to support every step of your immuno-oncology research journey.

Reference

Kusnick, Johanna, et al. "Ferroptosis in cancer immunotherapy—implications for hepatocellular carcinoma." Immuno 2.1 (2022): 185-217. Distributed under Open Access license CC BY 4.0, without modification.

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