Immune Checkpoints based Antibody Efficacy Assessment Service

Immune checkpoints, as a crucial mechanism, are responsible for regulating the balance between activation and inhibition in the immune system. With their significant success in cancer treatment, the importance of immune checkpoints in infectious disease research has become increasingly prominent. Particularly in the development of antibodies drugs, precise regulation of immune checkpoints can significantly enhance therapeutic efficacy. Creative Biolabs, a leader in the biotechnology field, is dedicated to providing cutting-edge antibody efficacy assessment services based on immune checkpoints to global scientific researchers, aiming to promote the development of infectious disease research and antibody therapies.

Immune Checkpoint Explanation

Immune checkpoints are key molecular components in the immune system, playing a central role in regulating the activity of immune cells. Molecules such as PD-1, CTLA-4, primarily expressed on the surface of immune cells, finely regulate the activation and inhibition of T cells through binding with their ligands, thereby maintaining the stable state of the immune system. In various infectious diseases, pathogens often evade the host's immune attack through these mechanisms. Therefore, by precisely intervening in these immune checkpoints, candidate drugs can activate the immune system and effectively clear pathogens.

Why Conduct Immune Checkpoint-Based Testing?

• Regulating Immune Response: Immune checkpoint molecules regulate immune cells, especially T cells' activity, enabling the immune system to appropriately respond to foreign pathogens. In infectious disease treatment research, effectively modulating these molecules with candidate antibodies can significantly enhance the body's immune response to pathogens.
• Overcoming Immune Evasion: Many pathogens evade host immune attacks by manipulating immune checkpoint mechanisms. Testing and developing candidate antibodies that can intervene in these mechanisms help the immune system identify and eliminate pathogens.
• Aiding Precise Drug Development: Through immune checkpoint-based testing, researchers can gain a deeper understanding of a drug's impact on the immune system, leading to the development of more precise and effective treatment methods.
• Assessing Drug Safety: Understanding the interaction between candidate antibodies and immune checkpoints is crucial for assessing potential side effects in clinical trials and ensuring drug safety.

Innovative Service Process at Creative Biolabs

1. Sample Preparation: Customers can provide or have Creative Biolabs prepare the relevant antibody samples.

2. Experimental Design: Develop a detailed experimental plan based on the target immune checkpoints, cell lines, and experimental requirements.

3. Functional Testing: Including but not limited to:

• Immune checkpoint binding affinity assessment.
• T cell activation/inhibition testing.
• Cytokine release analysis.
• Immune cell phenotype analysis.
• Immune cell signaling pathway research.

4. Mechanism Analysis: Thoroughly explore how antibodies regulate immune checkpoint activity and their impact on immune cell function.

Creative Biolabs is committed to supporting clients in developing innovative infectious disease treatment drugs. If you are interested in testing the potential impact of your candidate antibodies on immune checkpoints, please contact us. We look forward to creating the future together with you.