Creative Biolabs provides an effective and precise vector construction service to help clients easily construct ideal vectors for antibody expression. Our services cover the full range of immunogen fragment identification, vector construction, codon optimization, label selection, and expression vector selection to facilitate the antibody drug discovery process.
We will first assist in identifying suitable immunogen fragments. You can provide your own immunogens or choose from our immunogen library. Parameters such as the length and location of the immunogen fragment will be selected based on your specific application and demand to ensure the best possible immune specificity and efficacy.
Our vector construction service includes the insertion of immunogen genes into appropriate plasmids or viral vectors to ensure their stability and expression efficiency. Our experts will select the most suitable vectors (including plasmids, viral vectors, etc.) according to your requirements and the characteristics of the target proteins and ensure the accuracy and integrity of the insertion sequences. In addition, we can also customize the design for your specific application scenario.
In order to improve the expression level of antibody proteins, we will provide you with codon sequence optimization services. Using reliable algorithms and databases, we will perform codon optimization of immunogenic genes to improve their expression efficiency and stability in different host cells.
To facilitate the subsequent antibody purification and detection, we will provide you with a variety of tags available, such as His-tag, FLAG-tag, and so on. You can choose the appropriate tag according to your specific needs.
We will provide you with a variety of expression vectors, including plasmids, viral vectors and so on. It is possible to choose expression vectors suitable for antibody types and application scenarios to ensure efficient expression and correct folding of antibody proteins. Moreover, our multiple expression system platforms meet the requirements of various downstream applications, such as E. coli expression system and mammalian cell expression system.
Fig.1 Illustration of the co-culture method for the production of bispecific antibodies in E. coli systems.1
Creative Biolabs is committed to providing clients with an efficient and personalized vector construction service. Please contact us for a proposal.
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