Recombinant Anti-BAFF x Anti-B7RP1 Bispecific Antibody (F(ab')2-scFv2) (BABFV-018)

Recombinant Anti-BAFF x Anti-B7RP1 Bispecific Antibody (F(ab')2-scFv2) is designed to be expressed as two chains combined via a hinge region. The scFv of the anti-BAFF specificity is fused to the C terminus of the anti-B7RP1 Fab fragment, or vice versa. This format comprises four binding sites (two same scFv regions and two same Fab fragments), two for each antigen. This BsAb can bind and inactivate two ligands simultaneously. It can inhibit B cell survival and T cell costimulation. It is designed for the research of Systemic lupus erythematosus (SLE) therapy.

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Specifications

Targets

BAFF & B7RP1

Type

Fab-Fc Fusion Proteins

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Systemic lupus erythematosus (SLE)

Targets

Target 1

BAFF

Gene ID

10673

UniProt ID

Q9Y275

Alternative Names

TNFSF13B; TNF superfamily member 13b; DTL; B cell activating factor; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20

Target 2

B7RP1

Gene ID

23308

UniProt ID

O75144

Alternative Names

ICOSLG; inducible T cell costimulator ligand; B7H2; GL50; B7-H2; B7related protein; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-BAFF x Anti-B7RP1 Bispecific Antibody (F(ab')2-scFv2) (CAT#: BABFV-018)

Specifications

Targets

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