Recombinant Anti-BAFF x Anti-B7RP1 Bispecific Antibody (scFv-IgG) (BSSG-018)

Recombinant Anti-BAFF x Anti-B7RP1 Bispecific Antibody (scFv-IgG) is formed by an IgG and two scFv fragments. The scFvs from an anti-BAFF antibody variable domain are respectively connected to the N terminus of the anti-B7RP1 IgG heavy chains or light chains to form scFv-(H)IgG or scFv-(L)IgG. It is a type of appended IgGs and has 2+2 antigen-binding valency. This BsAb can bind and inactivate two ligands simultaneously. It can inhibit B cell survival and T cell costimulation. It is designed for the research of Systemic lupus erythematosus (SLE) therapy.

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Specifications

Targets

BAFF & B7RP1

Type

Appended IgGs

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Systemic lupus erythematosus (SLE)

Targets

Target 1

BAFF

Gene ID

10673

UniProt ID

Q9Y275

Alternative Names

TNFSF13B; TNF superfamily member 13b; DTL; B cell activating factor; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20

Target 2

B7RP1

Gene ID

23308

UniProt ID

O75144

Alternative Names

ICOSLG; inducible T cell costimulator ligand; B7H2; GL50; B7-H2; B7related protein; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-BAFF x Anti-B7RP1 Bispecific Antibody (scFv-IgG) (CAT#: BSSG-018)

Specifications

Targets

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